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- W2885660219 abstract "Endothelial cells play a key role in human body, including being a mechanical barrier between intravascular and extravascular fluids and playing a role in hemostasis, blood coagulation, inflammatory process, vasodilation and vasoconstriction. When endothelial cells are insulted, they lose their function, so called endothelial dysfunction. Consequently, prothrombotic, procoagulating and proinflammatory conditions are developed. Causes of endothelial dysfunction include mechanical stress, such as hypertension and oxidative stress, resulted from hypercholesterolemia and hyperglycemia. Such stresses suppress nitric oxide (NO) synthesis, but induce endothelin-1 synthesis. Decreases in NO synthesis are, at least, partially mediated by augmented levels of asymmetry dimethylarginine (ADMA). There are associations between ADMA levels and kidney diseases and cardiovascular diseases. In addition, endothelial dysfunction leads to upregulation of adhesion molecules on endothelial cell surface, causing inflammation and atherosclerotic lesion. Previous reports have shown change in markers of endothelial dysfunction, including ADMA, endothelin-1 and angiotensin II and these markers are associated with prognosis of kidney diseases and risk of cardiovascular diseases. Study in mechanisms and markers of endothelial dysfunction, therefore, are important for discovery of target treatment and delaying the progression of kidney diseases." @default.
- W2885660219 created "2018-08-22" @default.
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- W2885660219 date "2017-12-01" @default.
- W2885660219 modified "2023-09-23" @default.
- W2885660219 title "Endothelial Dysfunction in Chronic Kidney Disease" @default.
- W2885660219 hasPublicationYear "2017" @default.
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