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• W2885672714 abstract "In the present review, we will discuss the evidence and the mechanisms underlying the complex interplay between obesity, mineralocorticoid receptor activation, and cardiovascular dysfunction with special emphasis on the pathogenesis of cardiovascular disease (CVD) in obese and insulin-resistant females. Since the initial isolation of aldosterone in 1953 and the cloning of the mineralocorticoid receptor (MR) decades later, our understanding has expanded tremendously regarding their involvement in the pathogenesis of CVD. Recent results from both pre-clinical and clinical studies support a close correlation between increase adiposity and enhanced aldosterone production (MR activation). Importantly, insulin resistance and obese females are more prone to the deleterious cardiovascular effects of MR activation, and enhanced MR activation in females has emerged as an important causative event in the genesis of a more severe CVD in diabetic women. Different clinical trials have been completed examining the effect of MR blockade in subjects with CVD. Despite its important beneficial mortality impact, side effects are frequent and a newer MR antagonist, finerenone, with less risk of hyperkalemia is currently being tested in large clinical trials." @default.
• W2885672714 created "2018-08-22" @default.
• W2885672714 creator A5023010276 @default.
• W2885672714 creator A5058200158 @default.
• W2885672714 creator A5061165026 @default.
• W2885672714 date "2018-08-14" @default.
• W2885672714 modified "2023-09-24" @default.
• W2885672714 title "Mineralocorticoids and Cardiovascular Disease in Females with Insulin Resistance and Obesity" @default.
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• W2885672714 doi "https://doi.org/10.1007/s11906-018-0887-6" @default.
• W2885672714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6580424" @default.
• W2885672714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30109433" @default.
• W2885672714 hasPublicationYear "2018" @default.
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