Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885673883> ?p ?o ?g. }
- W2885673883 endingPage "196" @default.
- W2885673883 startingPage "189" @default.
- W2885673883 abstract "The recent development of single-cell RNA sequencing has deepened our understanding of the cell as a functional unit, providing new insights based on gene expression profiles of hundreds to hundreds of thousands of individual cells, and revealing new populations of cells with distinct gene expression profiles previously hidden within analyses of gene expression performed on bulk cell populations. However, appropriate analysis and utilization of the massive amounts of data generated from single-cell RNA sequencing experiments are challenging and require an understanding of the experimental and computational pathways taken between preparation of input cells and output of interpretable data. In this review, we will discuss the basic principles of these new technologies, focusing on concepts important in the analysis of single-cell RNA-sequencing data. Specifically, we summarize approaches to quality-control measures for determination of which single cells to include for further examination, methods of data normalization and scaling to overcome the relatively inefficient capture rate of mRNA from each cell, and clustering and visualization algorithms used for dimensional reduction of the data to a two-dimensional plot." @default.
- W2885673883 created "2018-08-22" @default.
- W2885673883 creator A5012951558 @default.
- W2885673883 creator A5016242084 @default.
- W2885673883 creator A5020688388 @default.
- W2885673883 date "2018-09-01" @default.
- W2885673883 modified "2023-10-12" @default.
- W2885673883 title "An Introduction to the Analysis of Single-Cell RNA-Sequencing Data" @default.
- W2885673883 cites W1481493019 @default.
- W2885673883 cites W1813068103 @default.
- W2885673883 cites W1829201672 @default.
- W2885673883 cites W1979834988 @default.
- W2885673883 cites W1982729887 @default.
- W2885673883 cites W1984883254 @default.
- W2885673883 cites W2001704836 @default.
- W2885673883 cites W2003571703 @default.
- W2885673883 cites W2016005198 @default.
- W2885673883 cites W2019552331 @default.
- W2885673883 cites W2025828346 @default.
- W2885673883 cites W2068767807 @default.
- W2885673883 cites W2068881679 @default.
- W2885673883 cites W2069089843 @default.
- W2885673883 cites W2071128523 @default.
- W2885673883 cites W2084942072 @default.
- W2885673883 cites W2102212449 @default.
- W2885673883 cites W2107018762 @default.
- W2885673883 cites W2108738634 @default.
- W2885673883 cites W2110768394 @default.
- W2885673883 cites W2112058982 @default.
- W2885673883 cites W2121690903 @default.
- W2885673883 cites W2128227827 @default.
- W2885673883 cites W2130852655 @default.
- W2885673883 cites W2135937351 @default.
- W2885673883 cites W2137526110 @default.
- W2885673883 cites W2140258573 @default.
- W2885673883 cites W2146512944 @default.
- W2885673883 cites W2152532695 @default.
- W2885673883 cites W2152544605 @default.
- W2885673883 cites W2155536866 @default.
- W2885673883 cites W2170819005 @default.
- W2885673883 cites W2179438025 @default.
- W2885673883 cites W2193667971 @default.
- W2885673883 cites W2227231914 @default.
- W2885673883 cites W2264578395 @default.
- W2885673883 cites W2286142055 @default.
- W2885673883 cites W2295523269 @default.
- W2885673883 cites W2336576680 @default.
- W2885673883 cites W2340974016 @default.
- W2885673883 cites W2342688693 @default.
- W2885673883 cites W2343956310 @default.
- W2885673883 cites W2500714154 @default.
- W2885673883 cites W2508002496 @default.
- W2885673883 cites W2516455020 @default.
- W2885673883 cites W2540833380 @default.
- W2885673883 cites W2575789909 @default.
- W2885673883 cites W2578839378 @default.
- W2885673883 cites W2605249439 @default.
- W2885673883 cites W2605611918 @default.
- W2885673883 cites W2605810679 @default.
- W2885673883 cites W2738946651 @default.
- W2885673883 cites W2740583344 @default.
- W2885673883 cites W2746479894 @default.
- W2885673883 cites W2747545374 @default.
- W2885673883 cites W2747877289 @default.
- W2885673883 cites W2750899741 @default.
- W2885673883 cites W2755506013 @default.
- W2885673883 cites W2757764553 @default.
- W2885673883 cites W2760824708 @default.
- W2885673883 cites W2760895042 @default.
- W2885673883 cites W2773573309 @default.
- W2885673883 cites W2779910850 @default.
- W2885673883 cites W2786402081 @default.
- W2885673883 cites W2788837643 @default.
- W2885673883 cites W2789569830 @default.
- W2885673883 cites W2789798853 @default.
- W2885673883 cites W2790925947 @default.
- W2885673883 cites W2791285756 @default.
- W2885673883 cites W2791400496 @default.
- W2885673883 cites W2792294474 @default.
- W2885673883 cites W2792855672 @default.
- W2885673883 cites W2794765397 @default.
- W2885673883 cites W2794891507 @default.
- W2885673883 cites W2800467109 @default.
- W2885673883 cites W2800642627 @default.
- W2885673883 cites W2801762127 @default.
- W2885673883 cites W2802720142 @default.
- W2885673883 cites W2803144214 @default.
- W2885673883 cites W2803948098 @default.
- W2885673883 cites W2804846329 @default.
- W2885673883 cites W2805415936 @default.
- W2885673883 cites W2949800632 @default.
- W2885673883 cites W2950862527 @default.
- W2885673883 cites W2951158909 @default.
- W2885673883 cites W2952343320 @default.
- W2885673883 cites W2969386006 @default.
- W2885673883 doi "https://doi.org/10.1016/j.omtm.2018.07.003" @default.
- W2885673883 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6072887" @default.
- W2885673883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30094294" @default.