FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885677042> ?p ?o ?g. }

• W2885677042 abstract "Functional analyses of genes responsible for neurodegenerative disorders have unveiled critical links between neurodegenerative processes and key developmental signalling pathways. Mutations in SPG4 encoding spastin cause hereditary spastic paraplegia (HSP). Spastin is involved in diverse cellular processes coupling microtubule severing to membrane remodelling. Two main spastin isoforms are synthesised from alternative translational start sites (M1 and M87). However, their specific roles in neuronal development and homeostasis remain largely unknown. To selectively unravel their neuronal function, we blocked Spastin synthesis from each initiation codon during zebrafish development and performed rescue analyses. The knockdown of each isoform led to different motoneuron and locomotion defects, which were not rescued by the selective expression of the other isoform. Notably, both morphant neuronal phenotypes were observed in a CRISPR/Cas9 spastin mutant. We next show that M1 spastin together with HSP proteins atlastin-1 and NIPA1 drive motor axon targeting by repressing BMP signalling, while M87 spastin acts downstream Neuropilin-1 to control motoneuron migration. Our data thus suggest that defective BMP and Neuropilin-1 signalling may contribute to the motor phenotype in a vertebrate model of spastin depletion." @default.
• W2885677042 created "2018-08-22" @default.
• W2885677042 creator A5016977893 @default.
• W2885677042 creator A5018494343 @default.
• W2885677042 creator A5028126885 @default.
• W2885677042 creator A5039114556 @default.
• W2885677042 creator A5043458784 @default.
• W2885677042 creator A5048308755 @default.
• W2885677042 creator A5055531810 @default.
• W2885677042 creator A5058185294 @default.
• W2885677042 creator A5065658439 @default.
• W2885677042 creator A5087462737 @default.
• W2885677042 date "2018-01-01" @default.
• W2885677042 modified "2023-10-11" @default.
• W2885677042 title "BMP- and Neuropilin-1-mediated motor axon navigation relies on spastin alternative translation" @default.
• W2885677042 cites W1498629854 @default.
• W2885677042 cites W1579964499 @default.
• W2885677042 cites W1591952754 @default.
• W2885677042 cites W1600720333 @default.
• W2885677042 cites W1625895411 @default.
• W2885677042 cites W1840470014 @default.
• W2885677042 cites W1894493322 @default.
• W2885677042 cites W1944222122 @default.
• W2885677042 cites W1969465539 @default.
• W2885677042 cites W1972259766 @default.
• W2885677042 cites W1972706019 @default.
• W2885677042 cites W1975075811 @default.
• W2885677042 cites W1993308396 @default.
• W2885677042 cites W1993354361 @default.
• W2885677042 cites W1996162288 @default.
• W2885677042 cites W1998053277 @default.
• W2885677042 cites W1998544646 @default.
• W2885677042 cites W2001175917 @default.
• W2885677042 cites W2004844618 @default.
• W2885677042 cites W2004986948 @default.
• W2885677042 cites W2005871950 @default.
• W2885677042 cites W2007783997 @default.
• W2885677042 cites W2007788777 @default.
• W2885677042 cites W2021981560 @default.
• W2885677042 cites W2023676328 @default.
• W2885677042 cites W2024984804 @default.
• W2885677042 cites W2028675856 @default.
• W2885677042 cites W2029871010 @default.
• W2885677042 cites W2034920745 @default.
• W2885677042 cites W2036380584 @default.
• W2885677042 cites W2036625045 @default.
• W2885677042 cites W2037525283 @default.
• W2885677042 cites W2038204861 @default.
• W2885677042 cites W2043714441 @default.
• W2885677042 cites W2052924105 @default.
• W2885677042 cites W2063518159 @default.
• W2885677042 cites W2066037819 @default.
• W2885677042 cites W2066252692 @default.
• W2885677042 cites W2068169334 @default.
• W2885677042 cites W2069782840 @default.
• W2885677042 cites W2071920745 @default.
• W2885677042 cites W2073384812 @default.
• W2885677042 cites W2082740138 @default.
• W2885677042 cites W2085554270 @default.
• W2885677042 cites W2085770677 @default.
• W2885677042 cites W2092766010 @default.
• W2885677042 cites W2093968864 @default.
• W2885677042 cites W2094769296 @default.
• W2885677042 cites W2095578584 @default.
• W2885677042 cites W2106440279 @default.
• W2885677042 cites W2110378485 @default.
• W2885677042 cites W2113117576 @default.
• W2885677042 cites W2117461700 @default.
• W2885677042 cites W2118241188 @default.
• W2885677042 cites W2118577405 @default.
• W2885677042 cites W2118647189 @default.
• W2885677042 cites W2119653094 @default.
• W2885677042 cites W2119804506 @default.
• W2885677042 cites W2124794865 @default.
• W2885677042 cites W2125349610 @default.
• W2885677042 cites W2129984820 @default.
• W2885677042 cites W2133361341 @default.
• W2885677042 cites W2133427405 @default.
• W2885677042 cites W2133739310 @default.
• W2885677042 cites W2150317079 @default.
• W2885677042 cites W2152152074 @default.
• W2885677042 cites W2152589229 @default.
• W2885677042 cites W2152592826 @default.
• W2885677042 cites W2152770646 @default.
• W2885677042 cites W2160394687 @default.
• W2885677042 cites W2165392243 @default.
• W2885677042 cites W2166723435 @default.
• W2885677042 cites W2170429063 @default.
• W2885677042 cites W2536120694 @default.
• W2885677042 cites W2605084038 @default.
• W2885677042 cites W2605245547 @default.
• W2885677042 cites W2767082699 @default.
• W2885677042 doi "https://doi.org/10.1242/dev.162701" @default.
• W2885677042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6141775" @default.
• W2885677042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30082270" @default.
• W2885677042 hasPublicationYear "2018" @default.
• W2885677042 type Work @default.
• W2885677042 sameAs 2885677042 @default.
• W2885677042 citedByCount "12" @default.
• W2885677042 countsByYear W28856770422019 @default.

• next