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- W2885686099 endingPage "845" @default.
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- W2885686099 abstract "Substance-naïve offspring from high-density alcohol use disorder (AUD) families exhibit altered subcortical brain volumes structurally and altered executive-functioning and emotion-processing functionally, compared with their peers. However, there is a dearth of literature exploring alterations of cortical thickness (CTh) in this population. T1-weighted structural brain MRI was acquired in 75 substance-naïve male offspring of treatment-seeking early onset (<25 years) AUD patients with high familial loading of AUDs (≥2 affected relatives) (FHP) and 65 age-matched substance-naïve male controls with negative family history from the community. Surface-based CTh reconstruction was done using FreeSurfer. Univariate general linear models were implemented at each vertex using SurfStat, controlling for age (linear and quadratic effects), and head size, to examine the main effect of familial AUD risk on CTh and its relationship with externalizing symptom score (ESS). A Johnson-Neyman procedure revealed that the main effect of familial AUD risk on CTh was seen during adolescence, where the FHP group had thicker cortices involving bilateral precentral gyri, left caudal middle frontal gyrus (MFG), bilateral temporo-parietal junction, left inferior-frontal gyrus and right inferior-temporal gyrus. Thicker cortices in left MFG and inferior-parietal lobule were also associated with greater ESS within both groups. More importantly, these group differences diminished with age by young adulthood. Familial AUD risk is associated with age-related differences in maturation of several higher order association cortices that are critical to ongoing development in executive function, emotion regulation and social cognition during adolescence. Early supportive intervention for a delay in alcohol initiation during this critical phase may be crucial for this at-risk population." @default.
- W2885686099 created "2018-08-22" @default.
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- W2885686099 creator A5047157394 @default.
- W2885686099 creator A5069096470 @default.
- W2885686099 date "2018-07-30" @default.
- W2885686099 modified "2023-10-18" @default.
- W2885686099 title "Altered brain cortical maturation is found in adolescents with a family history of alcoholism" @default.
- W2885686099 cites W1593583551 @default.
- W2885686099 cites W1755973449 @default.
- W2885686099 cites W1841749037 @default.
- W2885686099 cites W1868158529 @default.
- W2885686099 cites W1975561523 @default.
- W2885686099 cites W1982176826 @default.
- W2885686099 cites W1989430061 @default.
- W2885686099 cites W1994334609 @default.
- W2885686099 cites W1998019661 @default.
- W2885686099 cites W2000634053 @default.
- W2885686099 cites W2002783050 @default.
- W2885686099 cites W2003488688 @default.
- W2885686099 cites W2004293194 @default.
- W2885686099 cites W2005351217 @default.
- W2885686099 cites W2016899938 @default.
- W2885686099 cites W2021004335 @default.
- W2885686099 cites W2025311583 @default.
- W2885686099 cites W2033227860 @default.
- W2885686099 cites W2035380257 @default.
- W2885686099 cites W2037689983 @default.
- W2885686099 cites W2039475798 @default.
- W2885686099 cites W2046389763 @default.
- W2885686099 cites W2059021380 @default.
- W2885686099 cites W2059498859 @default.
- W2885686099 cites W2061397956 @default.
- W2885686099 cites W2062485818 @default.
- W2885686099 cites W2063018860 @default.
- W2885686099 cites W2065795241 @default.
- W2885686099 cites W2068287526 @default.
- W2885686099 cites W2072753696 @default.
- W2885686099 cites W2081810797 @default.
- W2885686099 cites W2082982612 @default.
- W2885686099 cites W2085143064 @default.
- W2885686099 cites W2086739383 @default.
- W2885686099 cites W2087399454 @default.
- W2885686099 cites W2089073546 @default.
- W2885686099 cites W2095048077 @default.
- W2885686099 cites W2102773298 @default.
- W2885686099 cites W2104356713 @default.
- W2885686099 cites W2106791461 @default.
- W2885686099 cites W2108424110 @default.
- W2885686099 cites W2110208125 @default.
- W2885686099 cites W2111479465 @default.
- W2885686099 cites W2113319997 @default.
- W2885686099 cites W2117090678 @default.
- W2885686099 cites W2118796430 @default.
- W2885686099 cites W2119251358 @default.
- W2885686099 cites W2120731293 @default.
- W2885686099 cites W2123171640 @default.
- W2885686099 cites W2123523993 @default.
- W2885686099 cites W2123940254 @default.
- W2885686099 cites W2126408001 @default.
- W2885686099 cites W2128104774 @default.
- W2885686099 cites W2131042456 @default.
- W2885686099 cites W2135007804 @default.
- W2885686099 cites W2139282762 @default.
- W2885686099 cites W2141125801 @default.
- W2885686099 cites W2144177438 @default.
- W2885686099 cites W2145729305 @default.
- W2885686099 cites W2146137783 @default.
- W2885686099 cites W2151344032 @default.
- W2885686099 cites W2151721316 @default.
- W2885686099 cites W2154089368 @default.
- W2885686099 cites W2156645869 @default.
- W2885686099 cites W2157270343 @default.
- W2885686099 cites W2157848968 @default.
- W2885686099 cites W2162693288 @default.
- W2885686099 cites W2168068466 @default.
- W2885686099 cites W2169321731 @default.
- W2885686099 cites W2278956258 @default.
- W2885686099 cites W2290550151 @default.
- W2885686099 cites W2526484688 @default.
- W2885686099 cites W2556590024 @default.
- W2885686099 cites W2572361501 @default.
- W2885686099 cites W2612458400 @default.
- W2885686099 cites W2741899195 @default.
- W2885686099 cites W2763540812 @default.
- W2885686099 cites W2765624956 @default.
- W2885686099 cites W2769966273 @default.
- W2885686099 cites W2794419405 @default.
- W2885686099 cites W4239141155 @default.
- W2885686099 cites W4318444801 @default.
- W2885686099 doi "https://doi.org/10.1111/adb.12662" @default.
- W2885686099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30058761" @default.
- W2885686099 hasPublicationYear "2018" @default.
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