FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885687544> ?p ?o ?g. }

• W2885687544 endingPage "e12474" @default.
• W2885687544 startingPage "e12474" @default.
• W2885687544 abstract "Objective We previously demonstrated the roflumilast inhibited cell proliferation and increased cell apoptosis in ovarian cancer. In this study, we aimed to investigate the roles of roflumilast in development of cisplatin (DDP)-sensitive and -resistant ovarian cancer. Methods OVCAR3 and SKOV3 were selected and the corresponding DDP-resistant cells were constructed. Cell viability, proliferation, apoptosis, cycle were performed. Expression cAMP, PKA, CREB, phosphorylation of CREB and FtMt were detected. The roles of roflumilast in development of DDP-sensitive and -resistant ovarian cancer were confirmed by xenograft model. Results Roflumilast + DDP inhibited cell proliferation, and induced cell apoptosis and G0/G1 arrest in OVCAR3 and SKOV3 cells, roflumilast induced expression of FtMt, the activity of cAMP and PKA and phosphorylation of CREB in ovarian cancer cells and the above-effect were inhibited by H89. Downregulation of CREB inhibited the roflumilast-increased DDP sensitivity of ovarian cancer cells, and the roflumilast-induced FtMt expression and phosphorylation of CREB. Also, roflumilast reversed cisplatin-resistance, and induced expression of FtMt and activation of cAMP/PKA/CREB in DDP-resistant ovarian cancer cells. Similarly, treated with H89 or downregulation of CREB inhibited the changes induced by roflumilast. In vivo, roflumilast inhibited the development of SKOV3 or SKOV3-DDP-R xenograft models. Conclusions Roflumilast enhanced DDP sensitivity and reversed the DDP resistance of ovarian cancer cells via activation of cAMP/PKA/CREB pathway and upregulation of the downstream FtMt expression, which has great promise in clinical treatment." @default.
• W2885687544 created "2018-08-22" @default.
• W2885687544 creator A5005025073 @default.
• W2885687544 creator A5035951209 @default.
• W2885687544 creator A5045212508 @default.
• W2885687544 creator A5051764626 @default.
• W2885687544 creator A5057020704 @default.
• W2885687544 creator A5059869015 @default.
• W2885687544 creator A5070312311 @default.
• W2885687544 creator A5087003182 @default.
• W2885687544 date "2018-08-02" @default.
• W2885687544 modified "2023-10-12" @default.
• W2885687544 title "Roflumilast enhances cisplatin-sensitivity and reverses cisplatin-resistance of ovarian cancer cells via cAMP/PKA/CREB-FtMt signalling axis" @default.
• W2885687544 cites W1974371672 @default.
• W2885687544 cites W1994292441 @default.
• W2885687544 cites W2016874927 @default.
• W2885687544 cites W2017396574 @default.
• W2885687544 cites W2021449942 @default.
• W2885687544 cites W2030350711 @default.
• W2885687544 cites W2043427243 @default.
• W2885687544 cites W2049390461 @default.
• W2885687544 cites W2054628563 @default.
• W2885687544 cites W2066469346 @default.
• W2885687544 cites W2077522116 @default.
• W2885687544 cites W2089265107 @default.
• W2885687544 cites W2091640827 @default.
• W2885687544 cites W2150246687 @default.
• W2885687544 cites W2184642485 @default.
• W2885687544 cites W2465798785 @default.
• W2885687544 cites W2509232842 @default.
• W2885687544 cites W2510680239 @default.
• W2885687544 cites W2510692080 @default.
• W2885687544 cites W2540862884 @default.
• W2885687544 cites W2541722955 @default.
• W2885687544 cites W2578257950 @default.
• W2885687544 cites W2585321129 @default.
• W2885687544 cites W2586739696 @default.
• W2885687544 cites W2594495563 @default.
• W2885687544 cites W2596236295 @default.
• W2885687544 cites W2612149813 @default.
• W2885687544 cites W2626020304 @default.
• W2885687544 cites W2730981140 @default.
• W2885687544 cites W2740437559 @default.
• W2885687544 cites W2765488911 @default.
• W2885687544 cites W2765585475 @default.
• W2885687544 cites W2766216537 @default.
• W2885687544 cites W2766902602 @default.
• W2885687544 cites W2767128515 @default.
• W2885687544 cites W2767173501 @default.
• W2885687544 cites W2768285356 @default.
• W2885687544 cites W2768881543 @default.
• W2885687544 cites W2771974037 @default.
• W2885687544 doi "https://doi.org/10.1111/cpr.12474" @default.
• W2885687544 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6528923" @default.
• W2885687544 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30069985" @default.
• W2885687544 hasPublicationYear "2018" @default.
• W2885687544 type Work @default.
• W2885687544 sameAs 2885687544 @default.
• W2885687544 citedByCount "15" @default.
• W2885687544 countsByYear W28856875442019 @default.
• W2885687544 countsByYear W28856875442020 @default.
• W2885687544 countsByYear W28856875442021 @default.
• W2885687544 countsByYear W28856875442022 @default.
• W2885687544 countsByYear W28856875442023 @default.
• W2885687544 crossrefType "journal-article" @default.
• W2885687544 hasAuthorship W2885687544A5005025073 @default.
• W2885687544 hasAuthorship W2885687544A5035951209 @default.
• W2885687544 hasAuthorship W2885687544A5045212508 @default.
• W2885687544 hasAuthorship W2885687544A5051764626 @default.
• W2885687544 hasAuthorship W2885687544A5057020704 @default.
• W2885687544 hasAuthorship W2885687544A5059869015 @default.
• W2885687544 hasAuthorship W2885687544A5070312311 @default.
• W2885687544 hasAuthorship W2885687544A5087003182 @default.
• W2885687544 hasBestOaLocation W28856875441 @default.
• W2885687544 hasConcept C104317684 @default.
• W2885687544 hasConcept C121608353 @default.
• W2885687544 hasConcept C126322002 @default.
• W2885687544 hasConcept C1629964 @default.
• W2885687544 hasConcept C185592680 @default.
• W2885687544 hasConcept C2776694085 @default.
• W2885687544 hasConcept C2776780178 @default.
• W2885687544 hasConcept C2778239845 @default.
• W2885687544 hasConcept C2778926808 @default.
• W2885687544 hasConcept C2780427987 @default.
• W2885687544 hasConcept C502942594 @default.
• W2885687544 hasConcept C55493867 @default.
• W2885687544 hasConcept C71924100 @default.
• W2885687544 hasConcept C86339819 @default.
• W2885687544 hasConcept C98274493 @default.
• W2885687544 hasConceptScore W2885687544C104317684 @default.
• W2885687544 hasConceptScore W2885687544C121608353 @default.
• W2885687544 hasConceptScore W2885687544C126322002 @default.
• W2885687544 hasConceptScore W2885687544C1629964 @default.
• W2885687544 hasConceptScore W2885687544C185592680 @default.
• W2885687544 hasConceptScore W2885687544C2776694085 @default.
• W2885687544 hasConceptScore W2885687544C2776780178 @default.
• W2885687544 hasConceptScore W2885687544C2778239845 @default.
• W2885687544 hasConceptScore W2885687544C2778926808 @default.

• next