FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885687654> ?p ?o ?g. }

• W2885687654 endingPage "e0006691" @default.
• W2885687654 startingPage "e0006691" @default.
• W2885687654 abstract "While primarily a mosquito-borne virus, Zika virus (ZIKV; genus Flavivirus in the Flaviviridae family) is capable of being sexually transmitted. Thirty to fifty percent of men with confirmed ZIKV infection shed ZIKV RNA in their semen, and prolonged viral RNA shedding in semen can occur for more than 6 months. The cellular reservoir of ZIKV in semen is unknown, although spermatozoa have been shown to contain ZIKV RNA and antigen. Yet, spermatozoa are not a requisite for sexual transmission, as at least one case of ZIKV sexual transmission involved a vasectomized man. To determine the cellular reservoirs of ZIKV in semen, an established animal model of sexual transmission was used. The majority of virus detected in the seminal fluid of infected mice during the peak timing of sexual transmission was from the supernatant fraction, suggesting cell-free ZIKV may be largely responsible for sexual transmission. However, some ZIKV RNA was cell-associated. In the testes and epididymides of infected mice, intracellular staining of ZIKV RNA was more pronounced in spermatogenic precursors (spermatocytes and spermatogonia) than in spermatids. Visualization of intracellular negative strand ZIKV RNA demonstrated ZIKV replication intermediates in leukocytes, immature spermatids and epididymal epithelial cells in the male urogenital tract. Epididymal epithelial cells were the principal source of negative-strand ZIKV RNA during the peak timing of sexual transmission potential, indicating these cells may be the predominant source of infectious cell-free ZIKV in seminal fluid. These data promote a more complete understanding of sexual transmission of ZIKV and will inform further model development for future studies on persistent ZIKV RNA shedding." @default.
• W2885687654 created "2018-08-22" @default.
• W2885687654 creator A5005452883 @default.
• W2885687654 creator A5062580884 @default.
• W2885687654 creator A5071498317 @default.
• W2885687654 creator A5087839244 @default.
• W2885687654 date "2018-08-02" @default.
• W2885687654 modified "2023-09-28" @default.
• W2885687654 title "Infection of epididymal epithelial cells and leukocytes drives seminal shedding of Zika virus in a mouse model" @default.
• W2885687654 cites W118722372 @default.
• W2885687654 cites W1484436219 @default.
• W2885687654 cites W1960653080 @default.
• W2885687654 cites W1995602103 @default.
• W2885687654 cites W2001384624 @default.
• W2885687654 cites W2030099636 @default.
• W2885687654 cites W2047939916 @default.
• W2885687654 cites W2056611927 @default.
• W2885687654 cites W2059638656 @default.
• W2885687654 cites W2059659140 @default.
• W2885687654 cites W2099395542 @default.
• W2885687654 cites W2123272922 @default.
• W2885687654 cites W2130635171 @default.
• W2885687654 cites W2168246972 @default.
• W2885687654 cites W2192931988 @default.
• W2885687654 cites W2201382378 @default.
• W2885687654 cites W2288868071 @default.
• W2885687654 cites W2296716561 @default.
• W2885687654 cites W2328723611 @default.
• W2885687654 cites W2522582513 @default.
• W2885687654 cites W2540278950 @default.
• W2885687654 cites W2556980854 @default.
• W2885687654 cites W2568971596 @default.
• W2885687654 cites W2588439609 @default.
• W2885687654 cites W2621511700 @default.
• W2885687654 cites W2741005213 @default.
• W2885687654 cites W2764311044 @default.
• W2885687654 cites W2785386287 @default.
• W2885687654 cites W2797088186 @default.
• W2885687654 doi "https://doi.org/10.1371/journal.pntd.0006691" @default.
• W2885687654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6091970" @default.
• W2885687654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30070988" @default.
• W2885687654 hasPublicationYear "2018" @default.
• W2885687654 type Work @default.
• W2885687654 sameAs 2885687654 @default.
• W2885687654 citedByCount "27" @default.
• W2885687654 countsByYear W28856876542018 @default.
• W2885687654 countsByYear W28856876542019 @default.
• W2885687654 countsByYear W28856876542020 @default.
• W2885687654 countsByYear W28856876542021 @default.
• W2885687654 countsByYear W28856876542022 @default.
• W2885687654 countsByYear W28856876542023 @default.
• W2885687654 crossrefType "journal-article" @default.
• W2885687654 hasAuthorship W2885687654A5005452883 @default.
• W2885687654 hasAuthorship W2885687654A5062580884 @default.
• W2885687654 hasAuthorship W2885687654A5071498317 @default.
• W2885687654 hasAuthorship W2885687654A5087839244 @default.
• W2885687654 hasBestOaLocation W28856876541 @default.
• W2885687654 hasConcept C104317684 @default.
• W2885687654 hasConcept C159047783 @default.
• W2885687654 hasConcept C197746943 @default.
• W2885687654 hasConcept C203014093 @default.
• W2885687654 hasConcept C2522874641 @default.
• W2885687654 hasConcept C2777053367 @default.
• W2885687654 hasConcept C2778093475 @default.
• W2885687654 hasConcept C3013748606 @default.
• W2885687654 hasConcept C3019340110 @default.
• W2885687654 hasConcept C54355233 @default.
• W2885687654 hasConcept C67705224 @default.
• W2885687654 hasConcept C86803240 @default.
• W2885687654 hasConceptScore W2885687654C104317684 @default.
• W2885687654 hasConceptScore W2885687654C159047783 @default.
• W2885687654 hasConceptScore W2885687654C197746943 @default.
• W2885687654 hasConceptScore W2885687654C203014093 @default.
• W2885687654 hasConceptScore W2885687654C2522874641 @default.
• W2885687654 hasConceptScore W2885687654C2777053367 @default.
• W2885687654 hasConceptScore W2885687654C2778093475 @default.
• W2885687654 hasConceptScore W2885687654C3013748606 @default.
• W2885687654 hasConceptScore W2885687654C3019340110 @default.
• W2885687654 hasConceptScore W2885687654C54355233 @default.
• W2885687654 hasConceptScore W2885687654C67705224 @default.
• W2885687654 hasConceptScore W2885687654C86803240 @default.
• W2885687654 hasIssue "8" @default.
• W2885687654 hasLocation W28856876541 @default.
• W2885687654 hasLocation W28856876542 @default.
• W2885687654 hasLocation W28856876543 @default.
• W2885687654 hasLocation W28856876544 @default.
• W2885687654 hasLocation W28856876545 @default.
• W2885687654 hasOpenAccess W2885687654 @default.
• W2885687654 hasPrimaryLocation W28856876541 @default.
• W2885687654 hasRelatedWork W1487857142 @default.
• W2885687654 hasRelatedWork W2048605031 @default.
• W2885687654 hasRelatedWork W2142935324 @default.
• W2885687654 hasRelatedWork W2521741667 @default.
• W2885687654 hasRelatedWork W2588439609 @default.
• W2885687654 hasRelatedWork W2764311044 @default.
• W2885687654 hasRelatedWork W2805774706 @default.
• W2885687654 hasRelatedWork W2883360095 @default.
• W2885687654 hasRelatedWork W2885687654 @default.

• next