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• W2885697306 startingPage "393884" @default.
• W2885697306 abstract "Transcriptional regulatory networks (TRNs) are enriched for certain network motifs. This could either be the result of natural selection for particular hypothesized functions of those motifs, or it could be a byproduct of mutation (e.g. of the prevalence of gene duplication) and of less specific forms of selection. We have developed a powerful new method for distinguishing between adaptive vs. non-adaptive causes, by simulating TRN evolution under different conditions. We simulate mutations to transcription factor binding sites in enough mechanistic detail to capture the high prevalence of weak-affinity binding sites, which can complicate the scoring of motifs. Our simulation of gene expression is also highly mechanistic, capturing stochasticity and delays in gene expression that distort external signals and intrinsically generate noise. We use the model to study a well-known motif, the type 1 coherent feed-forward loop (C1-FFL), which is hypothesized to filter out short spurious signals. We found that functional C1-FFLs evolve readily in TRNs under selection for this function, but not in a variety of negative controls. Interestingly, a new motif also emerged as a short spurious signal filter. Like the C1-FFL, the diamond integrates information from a fast pathway and a slow pathway, but their speeds are based on gene expression dynamics rather than topology. When there is no external spurious signal to filter out, but only internally generated noise, only the diamond and not the C1-FFL evolves." @default.
• W2885697306 created "2018-08-22" @default.
• W2885697306 creator A5023824766 @default.
• W2885697306 creator A5025186301 @default.
• W2885697306 creator A5041658734 @default.
• W2885697306 creator A5081790648 @default.
• W2885697306 date "2018-08-24" @default.
• W2885697306 modified "2023-09-24" @default.
• W2885697306 title "Adaptive evolution of feed-forward loops versus diamonds to filter out short spurious signals" @default.
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