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- W2885701764 abstract "Abstract The survival of viruses partly relies on their ability to self-assemble inside host cells. Although coarse-grained simulations have identified different pathways leading to assembled virions from their components, experimental evidence is severely lacking. Here, we use time-resolved small-angle X-ray scattering to uncover the nonequilibrium self-assembly dynamics of icosahedral viral capsids packaging their full RNA genome. We reveal the formation of amorphous complexes via an en masse pathway and their relaxation into virions via a synchronous pathway. The binding energy of capsid subunits on the genome is moderate (~7 k B T 0 , with k B the Boltzmann constant and T 0 = 298 K, the room temperature), while the energy barrier separating the complexes and the virions is high (~ 20 k B T 0 ). A synthetic polyelectrolyte can lower this barrier so that filled capsids are formed in conditions where virions cannot build up. We propose a representation of the dynamics on a free energy landscape." @default.
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- W2885701764 date "2018-08-06" @default.
- W2885701764 modified "2023-10-06" @default.
- W2885701764 title "Nonequilibrium self-assembly dynamics of icosahedral viral capsids packaging genome or polyelectrolyte" @default.
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- W2885701764 doi "https://doi.org/10.1038/s41467-018-05426-8" @default.
- W2885701764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6078970" @default.
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