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- W2885707631 abstract "Background: 3’,5’-cyclic adenosine monophosphate (cAMP) is an intracellular second messenger critically involved in the regulation of heart function. Signalling by cAMP in cardiomyocytes is organized in discrete functionally relevant microdomains formed for example around calcium-handling proteins. Previously, we have shown that β1-adrenergic receptor (β1AR) is evenly distributed across the whole membrane, including its localization in transverse (T)-tubules and the crest region. However, it is unknown whether these two β1AR pools, one located in T-tubules and another one in the crest, contribute differentially to the regulation of the cardiac contractility vs. pathological gene expression and can be used for more specific pharmacological manipulations." @default.
- W2885707631 created "2018-08-22" @default.
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- W2885707631 date "2018-07-01" @default.
- W2885707631 modified "2023-09-26" @default.
- W2885707631 title "Visualizing subcellular microdomains of β1-adrenergic receptor/cAMP signalling in cardiomyocytes by nanoscale live cell imaging" @default.
- W2885707631 doi "https://doi.org/10.1016/j.yjmcc.2018.05.124" @default.
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