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- W2885709297 abstract "The arterial pole of the heart is a hotspot for life-threatening forms of congenital heart defects (CHDs). It is formed by progressive addition of myocardium from epithelial progenitor cells in the second heart field (SHF). SHF cells contribute successively to the right ventricle and proximal and distal outflow tract myocardial walls which, after neural crest influx and cardiac septation, give rise to myocardium at the base of the aorta and pulmonary trunk. SHF cells are characterized by continued proliferation and differentiation delay controlled by an array of transcriptional regulators and signalling pathways which define the SHF progenitor cell niche in pharyngeal mesoderm. Failure of normal SHF deployment leads to a shortened outflow tract and failure of ventriculo-arterial alignment, resulting in a spectrum of conotruncal CHD. We discuss the origins of the SHF in cardiopharyngeal mesoderm and focus on the mechanisms driving SHF deployment, summarizing current understanding of critical signalling pathways and transcription factors." @default.
- W2885709297 created "2018-08-22" @default.
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- W2885709297 date "2018-08-01" @default.
- W2885709297 modified "2023-09-27" @default.
- W2885709297 title "Incorporation of myocardial progenitors at the arterial pole of the heart" @default.
- W2885709297 doi "https://doi.org/10.1093/med/9780198757269.003.0007" @default.
- W2885709297 hasPublicationYear "2018" @default.
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