FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885753557> ?p ?o ?g. }

• W2885753557 endingPage "2777" @default.
• W2885753557 startingPage "2765" @default.
• W2885753557 abstract "Hydatid cyst, the larval stage of the tapeworm Echinococcus granulosus and a causative agent of cystic echinococcosis, possesses a vast number of antigenic peptides that are constantly presented in the host immune system during infection. Here, we sought to provide more information about the cellular/humoral components engaged in the peripheral immune reactions to the fertile-cyst-derived Echinococcus alkaline phosphatase (E.ALP) in human hosts. Lymphoproliferative and cytokine responses after recall of E.ALP suggested the presence of specific immune reactions against the antigen. Interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), and interleukin (IL)-10 had the highest fold increase over the spontaneous levels in response to hydatid crude antigen (HCA). Recall of E.ALP, as well as its encounter, boosted IFN-γ, TNF-α, IL-2, and IL-6 responses in peripheral blood mononuclear cells cultures (PBMCs). The HCA-driven levels of all the cytokines in the culture supernatants of normal PBMCs were higher than those measured after E.ALP encounter. Immunoglobulin G (IgG)-profile in response to HCA showed the dominance of specific IgG1, IgG2, and IgG4 antibodies, but relatively lower affinity of IgG3 to this antigen. IgG1 and IgG3 were the only isotypes detected in serum responses to E.ALP. Our findings suggested that E.ALP contributes to the early phase of immune responses to the parasite, likely by induction of proinflammatory profiles and clonal expansion of high-affinity IgG1- and IgG3-secreting plasma cells, suggesting the value of E.ALP as a candidate to develop novel therapeutic and immunization strategies." @default.
• W2885753557 created "2018-08-22" @default.
• W2885753557 creator A5026272022 @default.
• W2885753557 creator A5026646179 @default.
• W2885753557 creator A5026909373 @default.
• W2885753557 creator A5052446606 @default.
• W2885753557 creator A5060110350 @default.
• W2885753557 creator A5067140213 @default.
• W2885753557 creator A5071764880 @default.
• W2885753557 date "2018-08-02" @default.
• W2885753557 modified "2023-10-16" @default.
• W2885753557 title "Characterization of cellular and humoral immune responses to alkaline phosphatase from fertile hydatid cysts in the human peripheral blood" @default.
• W2885753557 cites W1696337576 @default.
• W2885753557 cites W1883543096 @default.
• W2885753557 cites W1963502955 @default.
• W2885753557 cites W1965660723 @default.
• W2885753557 cites W1966774525 @default.
• W2885753557 cites W1967090364 @default.
• W2885753557 cites W1981421407 @default.
• W2885753557 cites W1984109590 @default.
• W2885753557 cites W1985988849 @default.
• W2885753557 cites W1994631242 @default.
• W2885753557 cites W1998596984 @default.
• W2885753557 cites W2003440042 @default.
• W2885753557 cites W2005308545 @default.
• W2885753557 cites W2020161022 @default.
• W2885753557 cites W2020822340 @default.
• W2885753557 cites W2022011723 @default.
• W2885753557 cites W2028631237 @default.
• W2885753557 cites W2046597603 @default.
• W2885753557 cites W2046652062 @default.
• W2885753557 cites W2048438396 @default.
• W2885753557 cites W2056969952 @default.
• W2885753557 cites W2058856567 @default.
• W2885753557 cites W2060807114 @default.
• W2885753557 cites W2069991038 @default.
• W2885753557 cites W2070616542 @default.
• W2885753557 cites W2071235186 @default.
• W2885753557 cites W2071449707 @default.
• W2885753557 cites W2076421941 @default.
• W2885753557 cites W2076994380 @default.
• W2885753557 cites W2094535104 @default.
• W2885753557 cites W2095963271 @default.
• W2885753557 cites W2096773270 @default.
• W2885753557 cites W2097147259 @default.
• W2885753557 cites W2097422527 @default.
• W2885753557 cites W2107453392 @default.
• W2885753557 cites W2109689202 @default.
• W2885753557 cites W2113893134 @default.
• W2885753557 cites W2126447740 @default.
• W2885753557 cites W2127509295 @default.
• W2885753557 cites W2128874417 @default.
• W2885753557 cites W2133874582 @default.
• W2885753557 cites W2136477237 @default.
• W2885753557 cites W2146136167 @default.
• W2885753557 cites W2146486722 @default.
• W2885753557 cites W2161075713 @default.
• W2885753557 cites W2169656611 @default.
• W2885753557 cites W2171093077 @default.
• W2885753557 cites W2220996713 @default.
• W2885753557 cites W2316113844 @default.
• W2885753557 cites W2591353285 @default.
• W2885753557 cites W3159675302 @default.
• W2885753557 cites W2088117280 @default.
• W2885753557 doi "https://doi.org/10.1002/jcp.27092" @default.
• W2885753557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30073650" @default.
• W2885753557 hasPublicationYear "2018" @default.
• W2885753557 type Work @default.
• W2885753557 sameAs 2885753557 @default.
• W2885753557 citedByCount "4" @default.
• W2885753557 countsByYear W28857535572019 @default.
• W2885753557 countsByYear W28857535572020 @default.
• W2885753557 countsByYear W28857535572021 @default.
• W2885753557 countsByYear W28857535572022 @default.
• W2885753557 crossrefType "journal-article" @default.
• W2885753557 hasAuthorship W2885753557A5026272022 @default.
• W2885753557 hasAuthorship W2885753557A5026646179 @default.
• W2885753557 hasAuthorship W2885753557A5026909373 @default.
• W2885753557 hasAuthorship W2885753557A5052446606 @default.
• W2885753557 hasAuthorship W2885753557A5060110350 @default.
• W2885753557 hasAuthorship W2885753557A5067140213 @default.
• W2885753557 hasAuthorship W2885753557A5071764880 @default.
• W2885753557 hasConcept C137061746 @default.
• W2885753557 hasConcept C147483822 @default.
• W2885753557 hasConcept C159654299 @default.
• W2885753557 hasConcept C160160445 @default.
• W2885753557 hasConcept C17991360 @default.
• W2885753557 hasConcept C181199279 @default.
• W2885753557 hasConcept C202751555 @default.
• W2885753557 hasConcept C203014093 @default.
• W2885753557 hasConcept C2776969849 @default.
• W2885753557 hasConcept C2777028278 @default.
• W2885753557 hasConcept C2780841837 @default.
• W2885753557 hasConcept C55493867 @default.
• W2885753557 hasConcept C86803240 @default.
• W2885753557 hasConcept C8891405 @default.
• W2885753557 hasConcept C90856448 @default.
• W2885753557 hasConceptScore W2885753557C137061746 @default.

• next