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- W2885755211 abstract "Although several genetic factors may play a role in leisure-time exercise behavior, there is currently no evidence of a significant genomewide association, and candidate gene replication studies have produced inconsistent results.We conducted a two-stage genomewide association study and candidate single-nucleotide polymorphisms (SNP) association study on leisure-time exercise behavior using 13,980 discovery samples from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study, and 2036 replication samples from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center-2 study. Leisure-time physical activity was measured using a self-administered questionnaire that inquired about the type, frequency and duration of exercise. Participants with ≥4 MET·h·wk of leisure-time physical activity were defined as exhibiting leisure-time exercise behavior. Association testing using mixed linear regression models was performed on the discovery and replication samples, after which the results were combined in a meta-analysis. In addition, we tested six candidate genetic variants derived from previous genomewide association study.We found that one novel SNP (rs10252228) located in the intergenic region between NPSR1 and DPY19L1 was significantly associated with leisure-time exercise behavior in discovery samples. This association was also significant in replication samples (combined P value by meta-analysis = 2.2 × 10). Several SNP linked with rs10252228 were significantly associated with gene expression of DPY19L1 and DP19L2P1 in skeletal muscle, heart, whole blood, and the nervous system. Among the candidate SNP, rs12612420 in DNAPTP6 demonstrated nominal significance in discovery samples but not in replication samples.We identified a novel genetic variant associated with regular leisure-time exercise behavior. Further functional studies are required to validate the role of these variants in exercise behavior." @default.
- W2885755211 created "2018-08-22" @default.
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- W2885755211 date "2018-12-01" @default.
- W2885755211 modified "2023-09-26" @default.
- W2885755211 title "Genomewide Association Study of Leisure-Time Exercise Behavior in Japanese Adults" @default.
- W2885755211 cites W146831418 @default.
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- W2885755211 cites W1966314702 @default.
- W2885755211 cites W1978212609 @default.
- W2885755211 cites W1980991473 @default.
- W2885755211 cites W1991704577 @default.
- W2885755211 cites W2002554863 @default.
- W2885755211 cites W2012610252 @default.
- W2885755211 cites W2033151532 @default.
- W2885755211 cites W2036067375 @default.
- W2885755211 cites W2036747758 @default.
- W2885755211 cites W2042197418 @default.
- W2885755211 cites W2046446443 @default.
- W2885755211 cites W2051314902 @default.
- W2885755211 cites W2052284306 @default.
- W2885755211 cites W2061539393 @default.
- W2885755211 cites W2073736874 @default.
- W2885755211 cites W2076149656 @default.
- W2885755211 cites W2076269514 @default.
- W2885755211 cites W2084096654 @default.
- W2885755211 cites W2094311270 @default.
- W2885755211 cites W2096528587 @default.
- W2885755211 cites W2096791516 @default.
- W2885755211 cites W2102270144 @default.
- W2885755211 cites W2108169091 @default.
- W2885755211 cites W2114538920 @default.
- W2885755211 cites W2122806520 @default.
- W2885755211 cites W2139821776 @default.
- W2885755211 cites W2150095859 @default.
- W2885755211 cites W2155496693 @default.
- W2885755211 cites W2157752701 @default.
- W2885755211 cites W2161633633 @default.
- W2885755211 cites W2163104142 @default.
- W2885755211 cites W2170267040 @default.
- W2885755211 cites W2170685496 @default.
- W2885755211 cites W2171129594 @default.
- W2885755211 cites W2208777739 @default.
- W2885755211 cites W2320147239 @default.
- W2885755211 cites W2325815304 @default.
- W2885755211 cites W2396832128 @default.
- W2885755211 cites W2559588208 @default.
- W2885755211 cites W2560290489 @default.
- W2885755211 cites W2563021430 @default.
- W2885755211 cites W2588720853 @default.
- W2885755211 cites W2752326665 @default.
- W2885755211 cites W2761275051 @default.
- W2885755211 cites W2768761371 @default.
- W2885755211 cites W2770967155 @default.
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- W2885755211 doi "https://doi.org/10.1249/mss.0000000000001712" @default.
- W2885755211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6282671" @default.
- W2885755211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30102679" @default.
- W2885755211 hasPublicationYear "2018" @default.