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- W2885756070 abstract "Abstract Following axon injury, a cascade of signaling events is triggered to initiate axon regeneration. However, the mechanisms regulating axon regeneration are not well understood at present. In Caenorhabditis elegans , axon regeneration utilizes many of the components involved in phagocytosis, including integrin and Rac GTPase. Here, we identify the transthyretin (TTR)-like protein TTR-11 as a component functioning in axon regeneration upstream of integrin. We show that TTR-11 binds to both the extracellular domain of integrin-α and phosphatidylserine (PS). Axon injury induces the accumulation of PS around the injured axons in a manner dependent on TTR-11, the ABC transporter CED-7, and the caspase CED-3. Furthermore, we demonstrate that CED-3 activates CED-7 during axon regeneration. Thus, TTR-11 functions to link the PS injury signal to activation of the integrin pathway, which then initiates axon regeneration." @default.
- W2885756070 created "2018-08-22" @default.
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- W2885756070 date "2018-08-06" @default.
- W2885756070 modified "2023-10-12" @default.
- W2885756070 title "Phosphatidylserine exposure mediated by ABC transporter activates the integrin signaling pathway promoting axon regeneration" @default.
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- W2885756070 doi "https://doi.org/10.1038/s41467-018-05478-w" @default.
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