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- W2885772875 abstract "Over 100 mammalian G protein-coupled receptors (GPCRs) are yet to be matched with endogenous ligands; these so-called ‘orphans’ offer hope as novel drug targets in the treatment of disease. One such orphan is GPR37L1; abundant in the brain and shown by our laboratory to be the first protease-inactivated GPCR. A previous study reports genetic deletion of GPR37L1 to cause hypertension and left ventricular hypertrophy (LVH) in mice. Hypothesising that GPR37L1 is a cardiovascular regulator, we investigated the cardiovascular role of GPR37L1 using knockout and reporter mice. GPR37L1wt/wt (WT) and GPR37L1ko/ko (KO) mice were subject to blood pressure (BP) measurement by micromanometry, and LVH was assessed by morphometry and qPCR assays for induction of the fetal gene programme. Intriguingly, we report that the previously described hypertensive phenotype of KO mice is limited to females, which had significantly (p≤0.05) elevated systolic (+11.6 mmHg), diastolic and mean arterial pressures, relative to WT, with ..." @default.
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- W2885772875 date "2016-11-11" @default.
- W2885772875 modified "2023-09-22" @default.
- W2885772875 title "Abstract 18096: Blood Pressure is Increased in Female Mice Lacking Orphan G Protein-Coupled Receptor Gpr37L1" @default.
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