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- W2885792686 endingPage "2907" @default.
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- W2885792686 abstract "Rapid advances in intensifying upstream processes for biologics production have left downstream processing as a bottleneck in the manufacturing scheme. Biomanufacturers are pursuing continuous downstream process development to increase efficiency and flexibility, reduce footprint and cost of goods, and improve product consistency and quality. Even after successful laboratory trials, the implementation of a continuous process at manufacturing scale is not easy to achieve. This paper reviews specific challenges in converting each downstream unit operation to a continuous mode. Key elements of developing practical strategies for overcoming these challenges are detailed. These include equipment valve complexity, favorable column aspect ratio, protein-A resin selection, quantitative assessment of chromatogram peak size and shape, holistic process characterization approach, and a customized process economic evaluation. Overall, this study provides a comprehensive review of current trends and the path forward for implementing continuous downstream processing at the manufacturing scale." @default.
- W2885792686 created "2018-08-22" @default.
- W2885792686 creator A5011086285 @default.
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- W2885792686 creator A5086346790 @default.
- W2885792686 date "2018-10-18" @default.
- W2885792686 modified "2023-10-18" @default.
- W2885792686 title "Progression of continuous downstream processing of monoclonal antibodies: Current trends and challenges" @default.
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- W2885792686 cites W1582192987 @default.
- W2885792686 cites W1599983274 @default.
- W2885792686 cites W1770883461 @default.
- W2885792686 cites W1906127102 @default.
- W2885792686 cites W1938323272 @default.
- W2885792686 cites W1970261045 @default.
- W2885792686 cites W1978889503 @default.
- W2885792686 cites W1980523265 @default.
- W2885792686 cites W1987920176 @default.
- W2885792686 cites W1988700176 @default.
- W2885792686 cites W1989444222 @default.
- W2885792686 cites W1995924547 @default.
- W2885792686 cites W1996059448 @default.
- W2885792686 cites W2006847242 @default.
- W2885792686 cites W2010948143 @default.
- W2885792686 cites W2015433122 @default.
- W2885792686 cites W2017762727 @default.
- W2885792686 cites W2018033335 @default.
- W2885792686 cites W2022074655 @default.
- W2885792686 cites W2022814920 @default.
- W2885792686 cites W2024391929 @default.
- W2885792686 cites W2034568372 @default.
- W2885792686 cites W2035312957 @default.
- W2885792686 cites W2038241066 @default.
- W2885792686 cites W2041067010 @default.
- W2885792686 cites W2044959209 @default.
- W2885792686 cites W2071312737 @default.
- W2885792686 cites W2073415267 @default.
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- W2885792686 cites W2076367767 @default.
- W2885792686 cites W2076708062 @default.
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- W2885792686 cites W2079642640 @default.
- W2885792686 cites W2080184981 @default.
- W2885792686 cites W2085423295 @default.
- W2885792686 cites W2090051042 @default.
- W2885792686 cites W2090712456 @default.
- W2885792686 cites W2094052190 @default.
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- W2885792686 cites W2112247421 @default.
- W2885792686 cites W2123713395 @default.
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- W2885792686 cites W2136022660 @default.
- W2885792686 cites W2142397163 @default.
- W2885792686 cites W2147288057 @default.
- W2885792686 cites W2147401031 @default.
- W2885792686 cites W2149717386 @default.
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- W2885792686 cites W2159334408 @default.
- W2885792686 cites W2168338758 @default.
- W2885792686 cites W2212436886 @default.
- W2885792686 cites W2233090823 @default.
- W2885792686 cites W2289965054 @default.
- W2885792686 cites W232994572 @default.
- W2885792686 cites W2331669079 @default.
- W2885792686 cites W2340027357 @default.
- W2885792686 cites W2343790881 @default.
- W2885792686 cites W2473190665 @default.
- W2885792686 cites W2489247779 @default.
- W2885792686 cites W2497847323 @default.
- W2885792686 cites W2525458303 @default.
- W2885792686 cites W2560383276 @default.
- W2885792686 cites W2597907100 @default.
- W2885792686 cites W2611980186 @default.
- W2885792686 cites W2619208021 @default.
- W2885792686 cites W2693798264 @default.
- W2885792686 cites W2735111094 @default.
- W2885792686 cites W2750279097 @default.
- W2885792686 cites W2767759534 @default.
- W2885792686 cites W2791683138 @default.
- W2885792686 cites W2794154985 @default.
- W2885792686 cites W2797522160 @default.
- W2885792686 cites W33426820 @default.
- W2885792686 cites W4237335235 @default.
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- W2885792686 cites W594755807 @default.
- W2885792686 cites W599104063 @default.
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- W2885792686 doi "https://doi.org/10.1002/bit.26812" @default.
- W2885792686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30080940" @default.
- W2885792686 hasPublicationYear "2018" @default.
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