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- W2885807357 abstract "Actin filament formation plays a pivotal role in the development, regeneration and modulation of the morphologies and physiological functions of subcellular compartments and entire cells. All of these processes require tight temporal and spatial control of F-actin assembly. Recent work has shed new light on the control of actin filament formation by Ca2+ as very fast, transient messenger allowing for defined responses to signal intensities spanning several orders of magnitude. Recent discoveries highlight that a small but rapidly growing set of actin nucleators and related proteins, i.e. factors that have the power to promote the formation of new actin filaments in cells, are tightly controlled by the Ca2+ sensor protein CaM. We here review the cellular functions and the molecular mechanisms that couple Ca2+ signaling to the cytoskeletal functions of these factors. This set of proteins currently includes one actin nucleator of the formin family (INF2), the WH2 domain-based actin nucleator Cobl and its ancestor protein Cobl-like as well as fesselin/synaptopodin-2/myopodin and myelin basic protein (MBP). Considering the mechanistic principles of Ca2+ control of actin filament formation unveiled thus far and the diverse cell biological processes involving Ca2+ signaling it is obvious that our understanding of the cell biological crosstalk of Ca2+ transients with the in part highly specialized actin cytoskeletal structures observed in different cell types is only at its infancy." @default.
- W2885807357 created "2018-08-22" @default.
- W2885807357 creator A5029180066 @default.
- W2885807357 creator A5036007300 @default.
- W2885807357 creator A5039999144 @default.
- W2885807357 creator A5074915363 @default.
- W2885807357 date "2018-11-01" @default.
- W2885807357 modified "2023-10-17" @default.
- W2885807357 title "Direct effects of Ca2+/calmodulin on actin filament formation" @default.
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- W2885807357 doi "https://doi.org/10.1016/j.bbrc.2018.07.159" @default.
- W2885807357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30093111" @default.
- W2885807357 hasPublicationYear "2018" @default.
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