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- W2885809407 abstract "目的 分析乳腺癌细胞系的基质金属蛋白酶-2(MMP-2)和纤维粘连蛋白(FN) mRNA表达及蛋白表达与乳腺癌转移的关系,阐明MMP-2和FN在乳腺癌转移中的作用.方法采用荧光定量逆转录-聚合酶链反应(RT-PCR)检测乳腺癌细胞系的MMP-2和FN mRNA表达量;采用Western blot方法检测细胞系的MMP-2和FN蛋白表达量.结果 MMP-2和FN的mRNA表达量在乳腺癌高转移细胞系MDA-MB-231、MDA-MB-435中表达下调,而在低转移细胞系MDA-453、T47D、SK-BR-3和不转移细胞系MCF-7、ZR-75-30表达上调.MMP-2和FN蛋白表达在高转移细胞系上调,而在低转移细胞系和不转移细胞系中下调.结论 MMP-2和FN mRNA表达和蛋白表达与乳腺癌转移相关,MMP-2和FN mRNA水平和蛋白水平的表达存在负反馈调节。" @default.
- W2885809407 created "2018-08-22" @default.
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- W2885809407 date "2005-05-08" @default.
- W2885809407 modified "2023-09-25" @default.
- W2885809407 title "Quantitative expression of MMP-2 and FN in high metastatic and low metastatic cell lines of breast cancer" @default.
- W2885809407 hasPublicationYear "2005" @default.
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