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• W2885824319 endingPage "1638" @default.
• W2885824319 startingPage "1623" @default.
• W2885824319 abstract "Breast cancer (BrCa) metabolism is geared toward biomass synthesis and maintenance of reductive capacity. Changes in glucose and glutamine metabolism in BrCa have been widely reported, yet the contribution of fatty acids ( FA s) in BrCa biology remains to be determined. We recently reported that adipocyte coculture alters MCF ‐7 and MDA ‐ MB ‐231 cell metabolism and promotes proliferation and migration. Since adipocytes are FA ‐rich, and these FA s are transferred to BrCa cells, we sought to elucidate the FA metabolism of BrCa cells and their response to FA ‐rich environments. MCF ‐7 and MDA ‐ MB ‐231 cells incubated in serum‐containing media supplemented with FA s accumulate extracellular FA s as intracellular triacylglycerols ( TAG ) in a dose‐dependent manner, with MDA ‐ MB ‐231 cells accumulating more TAG . The differences in TAG levels were a consequence of distinct differences in intracellular partitioning of FA s, and not due to differences in the rate of FA uptake. Specifically, MCF ‐7 cells preferentially partition FA s into mitochondrial oxidation, whereas MDA ‐ MB ‐231 cells partition FA s into TAG synthesis. These differences in intracellular FA handling underpin differences in the sensitivity to palmitate‐induced lipotoxicity, with MDA ‐ MB ‐231 cells being highly sensitive, whereas MCF ‐7 cells are partially protected. The attenuation of palmitate‐induced lipotoxicity in MCF ‐7 cells was reversed by inhibition of FA oxidation. Pretreatment of MDA ‐ MB ‐231 cells with FA s increased TAG synthesis and reduced palmitate‐induced apoptosis. Our results provide novel insight into the potential influences of obesity on BrCa biology, highlighting distinct differences in FA metabolism in MCF ‐7 and MDA ‐ MB ‐231 cells and how lipid‐rich environments modulate these effects." @default.
• W2885824319 created "2018-08-22" @default.
• W2885824319 creator A5037154747 @default.
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• W2885824319 date "2018-08-29" @default.
• W2885824319 modified "2023-09-30" @default.
• W2885824319 title "Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate‐induced apoptosis" @default.
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• W2885824319 doi "https://doi.org/10.1002/1878-0261.12368" @default.
• W2885824319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6120225" @default.
• W2885824319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30099850" @default.
• W2885824319 hasPublicationYear "2018" @default.
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