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- W2885850416 abstract "New pharmaceutical regulatory guidelines for reproductive studies have used closure of the hard palate as a developmental milestone for defining dosing periods to incorporate the stages of organogenesis. Timing of hard palate closure in Han Wistar rats and Harlan-Porcellus New Zealand White rabbits was determined by foetal examination on selected days of pregnancy. Closure of the hard palate was complete by Day 18 of pregnancy in rats and Day 21 of pregnancy in rabbits. Therefore in toxicity studies designed to detect effects on embryo and foetal development, the treatment period for these strains should include Day 17 of pregnancy in rats and Day 20 of pregnancy in rabbits." @default.
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- W2885850416 date "1996-01-01" @default.
- W2885850416 modified "2023-09-27" @default.
- W2885850416 title "To establish the timing of hard palate closure in Han Wistar rats and Harlan-Porcellus white rabbits" @default.
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