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- W2885862602 abstract "Introduction: The lipid nanoemulsion (LDE) binds intensely to LDL receptors due to similarity in molecular composition. Anti-proliferative agents paclitaxel (PTX) and methotrexate (MTX) may have beneficial effects on atherosclerosis by preventing proliferation of inflammatory cells and vascular smooth muscle cells. Hypothesis: By combining LDE to PTX and MTX, effective regression of hypercholesterolemic atherosclerosis and vascular inflammation occurs. Methods: Rabbits underwent induction of atherosclerosis by consuming a cholesterol diet for 8 weeks. Afterwards, 7 rabbits were sacrificed and had their aortas analyzed (Control group). The other rabbits had diet replaced by regular diet, and were divided into 3 groups (n=7 each), according to the 8-week treatment offered: LDE-PTX, LDE-PTX+MTX and Diet (no agent). The rabbits were then sacrificed and the aortas analyzed. Vascular tumor necrosis factor-α (TNF) gene expression was determined in all aorta samples. Results: See graph. LDE-PTX and LDE-PTX+MTX tr..." @default.
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- W2885862602 date "2016-11-11" @default.
- W2885862602 modified "2023-09-25" @default.
- W2885862602 title "Abstract 13994: Anti-cellular Proliferation Therapy Reduces Atherosclerotic Plaques and Vascular Inflammation in Experimental Hypercholesterolemia" @default.
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