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- W2885867066 endingPage "18" @default.
- W2885867066 startingPage "10" @default.
- W2885867066 abstract "Eosinophilic esophagitis (EoE) is a food allergen-induced inflammatory disorder. EoE is increasingly recognized as a cause of swallowing dysfunction, food impaction and esophageal stricture. Inflammation of the esophageal mucosa involves immune cell infiltrate, reactive epithelial changes and fibroblast activation, culminating in robust tissue remodeling toward esophageal fibrosis characterized by excess collagen deposition in the subepithelial lamina propria. Fibrosis contributes to a unique mechanical property of the EoE-affected esophagus that is substantially stiffer than the normal esophagus. There is a great need to better understand the processes behind esophageal fibrosis in order to foster improved diagnostic tools and novel therapeutics for EoE-related esophageal fibrosis. In this review, we discuss the role of esophageal inflammatory microenvironment that promotes esophageal fibrosis, with specific emphasis upon cytokines-mediated functional epithelial-stromal interplays, recruitment and activation of a variety of effector cells, and tissue stiffness. We then explore the current state of clinical methodologies to detect and treat the EoE-related esophageal stricture." @default.
- W2885867066 created "2018-08-22" @default.
- W2885867066 creator A5043169145 @default.
- W2885867066 creator A5052023689 @default.
- W2885867066 creator A5077168668 @default.
- W2885867066 date "2018-08-12" @default.
- W2885867066 modified "2023-10-17" @default.
- W2885867066 title "Epithelial-stromal crosstalk and fibrosis in eosinophilic esophagitis" @default.
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