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- W2885870 abstract "Imaging hypoxia using positron emission tomography (PET) is of great importance for therapy of cancer. [18F]Fluoromisonidazole (FMISO) was the first PET agent for hypoxia imaging, and various radiolabeled nitroimidazole derivatives such as [18F]fluoroerythronitroimidazole (FETNIM), [18F]1-α-d-(2-deoxy-2-fluoroarabinofuranosyl)-2-nitroimidazole (FAZA), [18F]2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide (EF-5), and [18F]fluoroetanidazole (FETA) have been developed successively. To overcome the high cost of cyclotron installation, 68Ga-labeled nitroimidazole derivatives also have been developed. Another important hypoxia imaging agent is 64Cu-diacetyl-bis(N 4-methylthiosemicarbazone) (64Cu-ATSM), which can distribute in cancer tissue rapidly due to high lipophilicity. However, its application is limited due to high cost of radionuclide production. Although various hypoxia imaging agents have been reported and tested, hypoxia PET images still have to be improved, because of the low blood flow in hypoxic tissues and resulting low uptake of the agents." @default.
- W2885870 created "2016-06-24" @default.
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- W2885870 date "2012-08-24" @default.
- W2885870 modified "2023-10-16" @default.
- W2885870 title "Hypoxia Imaging Agents Labeled with Positron Emitters" @default.
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- W2885870 doi "https://doi.org/10.1007/978-3-642-27994-2_15" @default.
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