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- W2885872902 endingPage "1800052" @default.
- W2885872902 startingPage "1800052" @default.
- W2885872902 abstract "Peptides are an emerging class of therapeutics in the pharmaceutical world. Whilst small molecules have dominated the therapeutic landscape for decades, the design and application of peptide drugs is emerging among the pharmaceutical industries and academia. Although highly selective and efficacious, peptides are characterized by poor pharmacokinetic properties and amelioration of their bioavailability remains a major hurdle. Incorporation of conformational constraints within the peptide (such as peptide stapling) has been extensively used to improve the bioavailability of these molecules; consequently, it is not surprising that a plethora of stapling techniques has been developed and has had a significant impact on the development of peptide therapeutics. Among the numerous stapling techniques known, two-component methodologies allow facile and divergent functionalization of peptides. The authors have pioneered a stapling technique that makes use of the double Cu-catalyzed azide–alkyne cycloaddition between di-azido peptides and functionalized di-alkynyl staples. In recent years, the authors have created biologically active, conformationally constrained peptides functionalized with cell-penetrating peptides, fluorescent tags, and photo cross-linking moieties, demonstrating the wide applicability of this methodology. Herein, the impact, advantages, limitations, and future applications of this technology and other two-component peptide stapling techniques on the development of clinically relevant peptides are highlighted." @default.
- W2885872902 created "2018-08-22" @default.
- W2885872902 creator A5001708763 @default.
- W2885872902 creator A5031476271 @default.
- W2885872902 creator A5058680543 @default.
- W2885872902 creator A5071380123 @default.
- W2885872902 creator A5075346091 @default.
- W2885872902 creator A5082661956 @default.
- W2885872902 date "2018-08-07" @default.
- W2885872902 modified "2023-10-17" @default.
- W2885872902 title "Two-Component Stapling of Biologically Active and Conformationally Constrained Peptides: Past, Present, and Future" @default.
- W2885872902 cites W1480294535 @default.
- W2885872902 cites W1576533924 @default.
- W2885872902 cites W1584439768 @default.
- W2885872902 cites W1584912962 @default.
- W2885872902 cites W1658545450 @default.
- W2885872902 cites W1859901295 @default.
- W2885872902 cites W1860382351 @default.
- W2885872902 cites W1897236478 @default.
- W2885872902 cites W1948609884 @default.
- W2885872902 cites W1965176789 @default.
- W2885872902 cites W1965819962 @default.
- W2885872902 cites W1967093877 @default.
- W2885872902 cites W1967671116 @default.
- W2885872902 cites W1968222033 @default.
- W2885872902 cites W1970106287 @default.
- W2885872902 cites W1973713421 @default.
- W2885872902 cites W1976159407 @default.
- W2885872902 cites W1978067561 @default.
- W2885872902 cites W1978999164 @default.
- W2885872902 cites W1981086097 @default.
- W2885872902 cites W1981300064 @default.
- W2885872902 cites W1982702481 @default.
- W2885872902 cites W1982782947 @default.
- W2885872902 cites W1983296334 @default.
- W2885872902 cites W1986239448 @default.
- W2885872902 cites W1991959327 @default.
- W2885872902 cites W1992114507 @default.
- W2885872902 cites W1992450378 @default.
- W2885872902 cites W1997099073 @default.
- W2885872902 cites W1998233841 @default.
- W2885872902 cites W1998645872 @default.
- W2885872902 cites W2001597478 @default.
- W2885872902 cites W2001976945 @default.
- W2885872902 cites W2002212889 @default.
- W2885872902 cites W2003746638 @default.
- W2885872902 cites W2008520119 @default.
- W2885872902 cites W2014171031 @default.
- W2885872902 cites W2020789636 @default.
- W2885872902 cites W2021632119 @default.
- W2885872902 cites W2023018411 @default.
- W2885872902 cites W2023557482 @default.
- W2885872902 cites W2023662718 @default.
- W2885872902 cites W2023697479 @default.
- W2885872902 cites W2029595514 @default.
- W2885872902 cites W2030738890 @default.
- W2885872902 cites W2031200468 @default.
- W2885872902 cites W2034265369 @default.
- W2885872902 cites W2040576705 @default.
- W2885872902 cites W2041492831 @default.
- W2885872902 cites W2041593863 @default.
- W2885872902 cites W2042061022 @default.
- W2885872902 cites W2042962257 @default.
- W2885872902 cites W2045172371 @default.
- W2885872902 cites W2045275149 @default.
- W2885872902 cites W2050585817 @default.
- W2885872902 cites W2062801269 @default.
- W2885872902 cites W2067990107 @default.
- W2885872902 cites W2068130700 @default.
- W2885872902 cites W2072435450 @default.
- W2885872902 cites W2074370114 @default.
- W2885872902 cites W2076357138 @default.
- W2885872902 cites W2078585784 @default.
- W2885872902 cites W2086572297 @default.
- W2885872902 cites W2089576018 @default.
- W2885872902 cites W2093715811 @default.
- W2885872902 cites W2095467897 @default.
- W2885872902 cites W2098061891 @default.
- W2885872902 cites W2098755986 @default.
- W2885872902 cites W2099404272 @default.
- W2885872902 cites W2101040826 @default.
- W2885872902 cites W2102899393 @default.
- W2885872902 cites W2104568794 @default.
- W2885872902 cites W2109598625 @default.
- W2885872902 cites W2110969535 @default.
- W2885872902 cites W2114982126 @default.
- W2885872902 cites W2121697537 @default.
- W2885872902 cites W2124736536 @default.
- W2885872902 cites W2133412871 @default.
- W2885872902 cites W2136032819 @default.
- W2885872902 cites W2138567388 @default.
- W2885872902 cites W2141267373 @default.
- W2885872902 cites W2142376954 @default.
- W2885872902 cites W2144873133 @default.
- W2885872902 cites W2145642736 @default.
- W2885872902 cites W2147369993 @default.
- W2885872902 cites W2162586071 @default.
- W2885872902 cites W2165023096 @default.