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- W2885873969 abstract "Abstract Evolutionary studies are often limited by missing data that are critical to understanding the history of selection. Selection experiments, which reproduce rapid evolution under controlled conditions, are excellent tools to study how genomes evolve under strong selection. Here we present a genomic dissection of the Longshanks selection experiment, in which mice were selectively bred over 20 generations for longer tibiae relative to body mass, resulting in 13% longer tibiae in two replicate lines. We synthesized evolutionary theory, genome sequences and molecular genetics to understand the selection response and found that it involved both polygenic adaptation and discrete loci of major effect, with the strongest loci likely to be selected in parallel between replicates. We show that selection may favor de-repression of bone growth through inactivation of two limb enhancers of an inhibitor, Nkx3-2 . Our integrative genomic analyses thus show that it is possible to connect individual base-pair changes to the overall selection response." @default.
- W2885873969 created "2018-08-22" @default.
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- W2885873969 date "2018-08-01" @default.
- W2885873969 modified "2023-10-16" @default.
- W2885873969 title "An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice" @default.
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- W2885873969 cites W1997640596 @default.
- W2885873969 cites W1999193893 @default.
- W2885873969 cites W2005501593 @default.
- W2885873969 cites W2008951609 @default.
- W2885873969 cites W2025250895 @default.
- W2885873969 cites W2026863186 @default.
- W2885873969 cites W2032590009 @default.
- W2885873969 cites W2032679444 @default.
- W2885873969 cites W2035998101 @default.
- W2885873969 cites W2038648128 @default.
- W2885873969 cites W2040597914 @default.
- W2885873969 cites W2042930277 @default.
- W2885873969 cites W2056783276 @default.
- W2885873969 cites W2056859934 @default.
- W2885873969 cites W2062036811 @default.
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- W2885873969 cites W2064941027 @default.
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- W2885873969 cites W2080843944 @default.
- W2885873969 cites W2102163928 @default.
- W2885873969 cites W2102326832 @default.
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- W2885873969 cites W2104511903 @default.
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- W2885873969 cites W2115669899 @default.
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- W2885873969 cites W2121032356 @default.
- W2885873969 cites W2129903198 @default.
- W2885873969 cites W2131271579 @default.
- W2885873969 cites W2133145771 @default.
- W2885873969 cites W2136145671 @default.
- W2885873969 cites W2139852278 @default.
- W2885873969 cites W2141212433 @default.
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- W2885873969 cites W2149992227 @default.
- W2885873969 cites W2151518299 @default.
- W2885873969 cites W2152022752 @default.
- W2885873969 cites W2162778907 @default.
- W2885873969 cites W2167852161 @default.
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- W2885873969 cites W2171808845 @default.
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- W2885873969 cites W2230276206 @default.
- W2885873969 cites W2259938310 @default.
- W2885873969 cites W2517379430 @default.
- W2885873969 cites W2586728725 @default.
- W2885873969 cites W2791143044 @default.
- W2885873969 cites W2806843613 @default.
- W2885873969 cites W2890193423 @default.
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- W2885873969 doi "https://doi.org/10.1101/378711" @default.
- W2885873969 hasPublicationYear "2018" @default.
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