FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885876106> ?p ?o ?g. }

• W2885876106 endingPage "1522" @default.
• W2885876106 startingPage "1511" @default.
• W2885876106 abstract "Abstract Proliferation of the adult hepatocyte population represents a central feature of tissue regeneration after liver injury and resection. This process could be driven by a diverse range of mitogens, such as hepatocyte growth factor (HGF) and fibroblast growth factor (FGF). Among FGF family, FGF2 is closely related to wound repair and cell proliferation. FGF2 does function in the process of angiogenesis in regenerating liver, while fewer reports are concerned with the impact and underlying mechanism of FGF2 on liver cell proliferation. To this end, an immortalized human normal hepatocyte L02 and mouse primary hepatocytes were exposed to FGF2 in this study. We demonstrate that FGF2 significantly enhances liver cell proliferation. Treatment with FGF2 obviously increases the phosphorylation level of extracellular signal‐regulated kinases 1 and 2 (ERK1/2) and c‐Jun N‐terminal kinase (JNK). Activity inhibition or expression down‐regulation prove that both ERK1/2 and JNK signaling are required for FGF2‐mediated effect on liver cell proliferation. Interestingly, interfering of ERK1/2 signaling results in marked decrease of JNK activation under FGF2 treatment, and JNK signaling is also involved in regulation of FGF2‐induced ERK1/2 activation, suggesting that cross‐talk between ERK1/2 and JNK signaling is important for FGF2 mitogenic activity. Both ERK1/2 and JNK signal via CREB to function in proliferation impact of FGF2 on liver cells. Taken together, this study reveals that ERK and JNK pathways synergistically regulate FGF2‐induced liver cell proliferation via phosphorylating CREB, which will contribute to the understanding of FGF2 impact on liver cell proliferation and liver regeneration." @default.
• W2885876106 created "2018-08-22" @default.
• W2885876106 creator A5002237394 @default.
• W2885876106 creator A5004914993 @default.
• W2885876106 creator A5025555679 @default.
• W2885876106 creator A5038326454 @default.
• W2885876106 creator A5053795352 @default.
• W2885876106 creator A5078128438 @default.
• W2885876106 date "2018-09-01" @default.
• W2885876106 modified "2023-10-14" @default.
• W2885876106 title "ERK1/2 and JNK signaling synergistically modulate mitogenic effect of fibroblast growth factor 2 on liver cell" @default.
• W2885876106 cites W1124228178 @default.
• W2885876106 cites W1496241668 @default.
• W2885876106 cites W1547736903 @default.
• W2885876106 cites W1923651867 @default.
• W2885876106 cites W1966187532 @default.
• W2885876106 cites W1972128179 @default.
• W2885876106 cites W1973487236 @default.
• W2885876106 cites W1976326383 @default.
• W2885876106 cites W1983132744 @default.
• W2885876106 cites W1984732140 @default.
• W2885876106 cites W1987827289 @default.
• W2885876106 cites W1992736578 @default.
• W2885876106 cites W1994123191 @default.
• W2885876106 cites W1996497126 @default.
• W2885876106 cites W1996632403 @default.
• W2885876106 cites W1997884729 @default.
• W2885876106 cites W1998420703 @default.
• W2885876106 cites W2022473934 @default.
• W2885876106 cites W2025870139 @default.
• W2885876106 cites W2026894807 @default.
• W2885876106 cites W2028874440 @default.
• W2885876106 cites W2041044388 @default.
• W2885876106 cites W2044788795 @default.
• W2885876106 cites W2050854749 @default.
• W2885876106 cites W2054195724 @default.
• W2885876106 cites W2055486839 @default.
• W2885876106 cites W2056983875 @default.
• W2885876106 cites W2069499945 @default.
• W2885876106 cites W2072303535 @default.
• W2885876106 cites W2082143463 @default.
• W2885876106 cites W2088011382 @default.
• W2885876106 cites W2089798340 @default.
• W2885876106 cites W2112678012 @default.
• W2885876106 cites W2117926291 @default.
• W2885876106 cites W2125613276 @default.
• W2885876106 cites W2130550745 @default.
• W2885876106 cites W2136701323 @default.
• W2885876106 cites W2138498601 @default.
• W2885876106 cites W2294781150 @default.
• W2885876106 cites W2563604790 @default.
• W2885876106 cites W2572843711 @default.
• W2885876106 cites W2597523916 @default.
• W2885876106 cites W2747265021 @default.
• W2885876106 cites W2753335511 @default.
• W2885876106 cites W2754757241 @default.
• W2885876106 cites W4254164242 @default.
• W2885876106 cites W89320799 @default.
• W2885876106 doi "https://doi.org/10.1002/cbin.11043" @default.
• W2885876106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30080297" @default.
• W2885876106 hasPublicationYear "2018" @default.
• W2885876106 type Work @default.
• W2885876106 sameAs 2885876106 @default.
• W2885876106 citedByCount "5" @default.
• W2885876106 countsByYear W28858761062019 @default.
• W2885876106 countsByYear W28858761062020 @default.
• W2885876106 countsByYear W28858761062021 @default.
• W2885876106 countsByYear W28858761062022 @default.
• W2885876106 crossrefType "journal-article" @default.
• W2885876106 hasAuthorship W2885876106A5002237394 @default.
• W2885876106 hasAuthorship W2885876106A5004914993 @default.
• W2885876106 hasAuthorship W2885876106A5025555679 @default.
• W2885876106 hasAuthorship W2885876106A5038326454 @default.
• W2885876106 hasAuthorship W2885876106A5053795352 @default.
• W2885876106 hasAuthorship W2885876106A5078128438 @default.
• W2885876106 hasConcept C104317684 @default.
• W2885876106 hasConcept C11960822 @default.
• W2885876106 hasConcept C1629964 @default.
• W2885876106 hasConcept C170493617 @default.
• W2885876106 hasConcept C171056886 @default.
• W2885876106 hasConcept C184235292 @default.
• W2885876106 hasConcept C2776795407 @default.
• W2885876106 hasConcept C2776996007 @default.
• W2885876106 hasConcept C55493867 @default.
• W2885876106 hasConcept C57074206 @default.
• W2885876106 hasConcept C62112901 @default.
• W2885876106 hasConcept C62478195 @default.
• W2885876106 hasConcept C74373430 @default.
• W2885876106 hasConcept C86339819 @default.
• W2885876106 hasConcept C86803240 @default.
• W2885876106 hasConcept C95444343 @default.
• W2885876106 hasConceptScore W2885876106C104317684 @default.
• W2885876106 hasConceptScore W2885876106C11960822 @default.
• W2885876106 hasConceptScore W2885876106C1629964 @default.
• W2885876106 hasConceptScore W2885876106C170493617 @default.
• W2885876106 hasConceptScore W2885876106C171056886 @default.
• W2885876106 hasConceptScore W2885876106C184235292 @default.
• W2885876106 hasConceptScore W2885876106C2776795407 @default.

• next