Matches in SemOpenAlex for { <https://semopenalex.org/work/W2885876476> ?p ?o ?g. }
- W2885876476 endingPage "109" @default.
- W2885876476 startingPage "101" @default.
- W2885876476 abstract "The interaction of atorvastatin with calf thymus DNA (CT-DNA) was investigated in vitro under simulated physiological conditions by using absorption and emission spectroscopy, viscosity measurements, gel electrophoresis and molecular docking studies. Analysis of UV-vis absorbance spectra indicates the formation of complex between atorvastatin and CT-DNA, and obtained binding constant (Kb = 8.2×104 L. mol-1) is comparable to groove binder drugs. Slight increase of viscosity of CT-DNA demonstrated the groove binding mode. Hoechst 33,258 and methylene blue (MB) displacement studies further confirmed such mode of atorvastatin interaction. Thermodynamic parameters ΔG, ΔH, and ΔS measurements were taken at different temperatures indicated that hydrophobic forces played main role in the binding process. Molecular docking provided detailed computational interaction of atorvastatin with CT-DNA which proved that atorvastatin binds to the groove of CT-DNA. Cleavage experiments showed that atorvastatin does not induce any cleavage under the experimental setup. Finally, all results indicated that atorvastatin interacts with CT-DNA via groove binding mode." @default.
- W2885876476 created "2018-08-22" @default.
- W2885876476 creator A5058650770 @default.
- W2885876476 date "2018-11-01" @default.
- W2885876476 modified "2023-09-29" @default.
- W2885876476 title "In vitro binding interaction of atorvastatin with calf thymus DNA: multispectroscopic, gel electrophoresis and molecular docking studies" @default.
- W2885876476 cites W1517723618 @default.
- W2885876476 cites W1914280947 @default.
- W2885876476 cites W1963706901 @default.
- W2885876476 cites W1966318010 @default.
- W2885876476 cites W1976520518 @default.
- W2885876476 cites W1984761981 @default.
- W2885876476 cites W1990032603 @default.
- W2885876476 cites W1990480779 @default.
- W2885876476 cites W1994999899 @default.
- W2885876476 cites W1995676112 @default.
- W2885876476 cites W1998340494 @default.
- W2885876476 cites W2007748309 @default.
- W2885876476 cites W2020555135 @default.
- W2885876476 cites W2022209253 @default.
- W2885876476 cites W2034380860 @default.
- W2885876476 cites W2049599520 @default.
- W2885876476 cites W2059853853 @default.
- W2885876476 cites W2067878166 @default.
- W2885876476 cites W2073696638 @default.
- W2885876476 cites W2075331880 @default.
- W2885876476 cites W2075705506 @default.
- W2885876476 cites W2085507557 @default.
- W2885876476 cites W2086382728 @default.
- W2885876476 cites W2087492305 @default.
- W2885876476 cites W2087550237 @default.
- W2885876476 cites W2097461802 @default.
- W2885876476 cites W2105668062 @default.
- W2885876476 cites W2131237328 @default.
- W2885876476 cites W2137271084 @default.
- W2885876476 cites W2140723383 @default.
- W2885876476 cites W2146751417 @default.
- W2885876476 cites W2148550663 @default.
- W2885876476 cites W2171557261 @default.
- W2885876476 cites W2256152172 @default.
- W2885876476 cites W2273689542 @default.
- W2885876476 cites W2324613566 @default.
- W2885876476 cites W2432084374 @default.
- W2885876476 cites W2519634482 @default.
- W2885876476 cites W2544341196 @default.
- W2885876476 cites W2578812784 @default.
- W2885876476 cites W2588759333 @default.
- W2885876476 cites W2613295083 @default.
- W2885876476 cites W2620325329 @default.
- W2885876476 cites W2624854612 @default.
- W2885876476 cites W2625887061 @default.
- W2885876476 cites W2751898785 @default.
- W2885876476 cites W2752862539 @default.
- W2885876476 cites W2756543466 @default.
- W2885876476 cites W2757296782 @default.
- W2885876476 cites W2766539732 @default.
- W2885876476 cites W2769486622 @default.
- W2885876476 cites W2775270697 @default.
- W2885876476 cites W2775885213 @default.
- W2885876476 cites W2792443771 @default.
- W2885876476 cites W2794128681 @default.
- W2885876476 cites W3021097810 @default.
- W2885876476 cites W5140127 @default.
- W2885876476 doi "https://doi.org/10.1016/j.jpba.2018.08.033" @default.
- W2885876476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30145447" @default.
- W2885876476 hasPublicationYear "2018" @default.
- W2885876476 type Work @default.
- W2885876476 sameAs 2885876476 @default.
- W2885876476 citedByCount "40" @default.
- W2885876476 countsByYear W28858764762019 @default.
- W2885876476 countsByYear W28858764762020 @default.
- W2885876476 countsByYear W28858764762021 @default.
- W2885876476 countsByYear W28858764762022 @default.
- W2885876476 countsByYear W28858764762023 @default.
- W2885876476 crossrefType "journal-article" @default.
- W2885876476 hasAuthorship W2885876476A5058650770 @default.
- W2885876476 hasConcept C107824862 @default.
- W2885876476 hasConcept C116084860 @default.
- W2885876476 hasConcept C12554922 @default.
- W2885876476 hasConcept C127413603 @default.
- W2885876476 hasConcept C159110408 @default.
- W2885876476 hasConcept C175156509 @default.
- W2885876476 hasConcept C185592680 @default.
- W2885876476 hasConcept C187320778 @default.
- W2885876476 hasConcept C202751555 @default.
- W2885876476 hasConcept C204389451 @default.
- W2885876476 hasConcept C2777482532 @default.
- W2885876476 hasConcept C32786932 @default.
- W2885876476 hasConcept C41685203 @default.
- W2885876476 hasConcept C43369102 @default.
- W2885876476 hasConcept C43617362 @default.
- W2885876476 hasConcept C552990157 @default.
- W2885876476 hasConcept C55493867 @default.
- W2885876476 hasConcept C71240020 @default.
- W2885876476 hasConcept C71924100 @default.
- W2885876476 hasConcept C86803240 @default.
- W2885876476 hasConcept C98015330 @default.
- W2885876476 hasConcept C98274493 @default.