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• W2885895890 startingPage "2372" @default.
• W2885895890 abstract "Background Increasing evidence indicates that renal recovery from AKI stems from dedifferentiation and proliferation of surviving tubule epithelial cells. Both EGF receptor (EGFR) and the Hippo signaling pathway are implicated in cell proliferation and differentiation, and previous studies showed that activation of EGFR in renal proximal tubule epithelial cells (RPTCs) plays a critical role in recovery from ischemia-reperfusion injury (IRI). In this study, we explored RPTC activation of Yes-associated protein (YAP) and transcriptional coactivator with PDZ binding motif (TAZ), two key downstream effectors of the Hippo pathway, and their potential involvement in recovery from AKI. Methods We used immunofluorescence to examine YAP expression in kidney biopsy samples from patients with clinical AKI and controls (patients with minimal change disease). Studies of RPTC activation of YAP and TAZ used cultured human RPTCs that were exposed to hypoxia-reoxygenation as well as knockout mice (with inducible deletions of Yap , Taz , or both occurring specifically in RPTCs) that were subjected to bilateral IRI. Results YAP was activated in RPTCs in kidneys from post-AKI patients and post-IRI mouse kidneys. Inhibition of the interaction of YAP and the TEA domain (TEAD) transcription factor complex by verteporfin or conditional deletion of YAP in RPTCs delayed renal functional and structural recovery from IRI, whereas TAZ deletion had no effect. Activation of the EGFR-PI3K-Akt pathway in response to IRI signaled YAP activation, which promoted cell cycle progression. Conclusions This study shows that EGFR-PI3K-Akt–dependent YAP activation plays an essential role in mediating epithelial cell regeneration during kidney recovery from AKI." @default.
• W2885895890 created "2018-08-22" @default.
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• W2885895890 date "2018-08-02" @default.
• W2885895890 modified "2023-10-16" @default.
• W2885895890 title "EGF Receptor–Dependent YAP Activation Is Important for Renal Recovery from AKI" @default.
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• W2885895890 cites W1977271040 @default.
• W2885895890 cites W1985657656 @default.
• W2885895890 cites W1986829962 @default.
• W2885895890 cites W1989945871 @default.
• W2885895890 cites W1993320949 @default.
• W2885895890 cites W1995160678 @default.
• W2885895890 cites W1995555853 @default.
• W2885895890 cites W1997973068 @default.
• W2885895890 cites W2003044806 @default.
• W2885895890 cites W2004102023 @default.
• W2885895890 cites W2006778392 @default.
• W2885895890 cites W2009682316 @default.
• W2885895890 cites W2018091219 @default.
• W2885895890 cites W2019442978 @default.
• W2885895890 cites W2022908161 @default.
• W2885895890 cites W2024424959 @default.
• W2885895890 cites W2030433725 @default.
• W2885895890 cites W2038136197 @default.
• W2885895890 cites W2049574005 @default.
• W2885895890 cites W2056102163 @default.
• W2885895890 cites W2056109978 @default.
• W2885895890 cites W2060073863 @default.
• W2885895890 cites W2060234615 @default.
• W2885895890 cites W2061058076 @default.
• W2885895890 cites W2063123103 @default.
• W2885895890 cites W2068446361 @default.
• W2885895890 cites W2075528452 @default.
• W2885895890 cites W2079869133 @default.
• W2885895890 cites W2083075830 @default.
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• W2885895890 cites W2086332492 @default.
• W2885895890 cites W2087154146 @default.
• W2885895890 cites W2089655089 @default.
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• W2885895890 cites W2100641053 @default.
• W2885895890 cites W2103977381 @default.
• W2885895890 cites W2117841435 @default.
• W2885895890 cites W2117868104 @default.
• W2885895890 cites W2117958746 @default.
• W2885895890 cites W2121072573 @default.
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• W2885895890 doi "https://doi.org/10.1681/asn.2017121272" @default.
• W2885895890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6115662" @default.
• W2885895890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30072422" @default.
• W2885895890 hasPublicationYear "2018" @default.
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