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- W2885994265 abstract "Abstract—Plasma cholesterol levels increase with age, as does the incidence of coronary heart disease. The mechanisms responsible for the age-related hypercholesterolemia are not well understood. An interesting hypothesis suggests that the relative deficiency in growth hormone (GH), which occurs with aging, contributes to the development of the age-related hypercholesterolemia, because GH has beneficial effects on cholesterol metabolism. In the present work, we tested this hypothesis by the administration of GH to normal rats of varying ages. Plasma lipids and hepatic cholesterol metabolism were characterized in 2-, 12-, and 18-month-old male Sprague-Dawley rats. In 2-month-old rats, GH specifically stimulated the hepatic low density lipoprotein (LDL) receptor expression in a dose-dependent way, both at the protein level and at the mRNA level. Concomitantly, plasma cholesterol increased by ≈30% within the large high density lipoprotein and LDL fractions. In 12-month-old animals, cholesterol 7α-hydroxylase..." @default.
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- W2885994265 date "1999-04-01" @default.
- W2885994265 modified "2023-09-26" @default.
- W2885994265 title "Cholesterol and Lipoprotein Metabolism in Aging" @default.
- W2885994265 hasPublicationYear "1999" @default.
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