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- W2886006282 abstract "The gate control theory proposes that Aβ mechanoreceptor inputs to spinal pain transmission T neurons are gated via feedforward inhibition, but it remains unclear how monosynaptic excitation is gated by disynaptic inhibitory inputs that arrive later. Here we report that Aβ-evoked, non-NMDAR-dependent EPSPs in T neurons are subthreshold, allowing time for inhibitory inputs to prevent action potential firing that requires slow-onset NMDAR activation. Potassium channel activities-including IA, whose sizes are established constitutively by PreprodynorphinCre-derived inhibitory neurons-either completely filter away Aβ inputs or make them subthreshold, thereby creating a permissive condition to achieve gate control. Capsaicin-activated nociceptor inputs reduce IA and sensitize the T neurons, allowing Aβ inputs to cause firing before inhibitory inputs arrive. Thus, distinct kinetics of glutamate receptors and electric filtering by potassium channels solve the timing problem underlying the gating by feedforward inhibition, and their modulation offers a way to bypass the gate control." @default.
- W2886006282 created "2018-08-22" @default.
- W2886006282 creator A5013125549 @default.
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- W2886006282 creator A5088189767 @default.
- W2886006282 creator A5090823484 @default.
- W2886006282 date "2018-09-01" @default.
- W2886006282 modified "2023-10-12" @default.
- W2886006282 title "Timing Mechanisms Underlying Gate Control by Feedforward Inhibition" @default.
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- W2886006282 doi "https://doi.org/10.1016/j.neuron.2018.07.026" @default.
- W2886006282 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6309466" @default.
- W2886006282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30122375" @default.
- W2886006282 hasPublicationYear "2018" @default.
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