Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886015910> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2886015910 abstract "Discoidin domain receptors DDR1 and DDR2 are the only receptor tyrosine kinases that bind to and signal in response to collagen. In cancer, DDRs have been shown to play a key role in mediating the crosstalk between tumor cells and the stromal collagen matrix. Because prostate cancer (PCa) preferentially metastasizes to bone, a collagen-rich microenvironment, we set out to investigate the role of DDR1 in intraosseous growth of PC3 cells, a human PCa cell line that expresses DDR1 but not DDR2. PC3 cells were engineered to express short hairpin RNAs (shRNAs) against DDR1, or a scrambled shRNA as a control. These cells were inoculated into the tibiae of male SCID mice, and then bone response and intraosseous tumor growth evaluated by X-ray and histomorphometry. Whereas no differences were observed in bone response (osteolytic lesions), downregulation of DDR1 in PC3 cells was associated with a significant increase in intraosseous tumor growth when compared to control PC3 cells (P Citation Format: R. Daniel Bonfil, Anjum Sohail, Semir Vranic, Daniel S. Oliveira, Dongping Shi, Wei Chen, Hyejeong Jang, Allen D. Saliganan, Benjamin D. Wasinski, Hyeong-Reh C. Kim, Rafael A. Fridman. Discoidin domain receptor 1 (DDR1): A potential suppressor of prostate cancer progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1070." @default.
- W2886015910 created "2018-08-22" @default.
- W2886015910 creator A5016334197 @default.
- W2886015910 creator A5023883545 @default.
- W2886015910 creator A5027863398 @default.
- W2886015910 creator A5033620992 @default.
- W2886015910 creator A5035773159 @default.
- W2886015910 creator A5045088400 @default.
- W2886015910 creator A5055160492 @default.
- W2886015910 creator A5063462261 @default.
- W2886015910 creator A5069485497 @default.
- W2886015910 creator A5087890448 @default.
- W2886015910 creator A5089718956 @default.
- W2886015910 date "2018-07-01" @default.
- W2886015910 modified "2023-10-14" @default.
- W2886015910 title "Abstract 1070: Discoidin domain receptor 1 (DDR1): A potential suppressor of prostate cancer progression" @default.
- W2886015910 doi "https://doi.org/10.1158/1538-7445.am2018-1070" @default.
- W2886015910 hasPublicationYear "2018" @default.
- W2886015910 type Work @default.
- W2886015910 sameAs 2886015910 @default.
- W2886015910 citedByCount "1" @default.
- W2886015910 countsByYear W28860159102020 @default.
- W2886015910 crossrefType "proceedings-article" @default.
- W2886015910 hasAuthorship W2886015910A5016334197 @default.
- W2886015910 hasAuthorship W2886015910A5023883545 @default.
- W2886015910 hasAuthorship W2886015910A5027863398 @default.
- W2886015910 hasAuthorship W2886015910A5033620992 @default.
- W2886015910 hasAuthorship W2886015910A5035773159 @default.
- W2886015910 hasAuthorship W2886015910A5045088400 @default.
- W2886015910 hasAuthorship W2886015910A5055160492 @default.
- W2886015910 hasAuthorship W2886015910A5063462261 @default.
- W2886015910 hasAuthorship W2886015910A5069485497 @default.
- W2886015910 hasAuthorship W2886015910A5087890448 @default.
- W2886015910 hasAuthorship W2886015910A5089718956 @default.
- W2886015910 hasBestOaLocation W28860159101 @default.
- W2886015910 hasConcept C101544691 @default.
- W2886015910 hasConcept C121608353 @default.
- W2886015910 hasConcept C126322002 @default.
- W2886015910 hasConcept C152681006 @default.
- W2886015910 hasConcept C16930146 @default.
- W2886015910 hasConcept C170493617 @default.
- W2886015910 hasConcept C2776305115 @default.
- W2886015910 hasConcept C2780192828 @default.
- W2886015910 hasConcept C502942594 @default.
- W2886015910 hasConcept C71924100 @default.
- W2886015910 hasConcept C86803240 @default.
- W2886015910 hasConceptScore W2886015910C101544691 @default.
- W2886015910 hasConceptScore W2886015910C121608353 @default.
- W2886015910 hasConceptScore W2886015910C126322002 @default.
- W2886015910 hasConceptScore W2886015910C152681006 @default.
- W2886015910 hasConceptScore W2886015910C16930146 @default.
- W2886015910 hasConceptScore W2886015910C170493617 @default.
- W2886015910 hasConceptScore W2886015910C2776305115 @default.
- W2886015910 hasConceptScore W2886015910C2780192828 @default.
- W2886015910 hasConceptScore W2886015910C502942594 @default.
- W2886015910 hasConceptScore W2886015910C71924100 @default.
- W2886015910 hasConceptScore W2886015910C86803240 @default.
- W2886015910 hasLocation W28860159101 @default.
- W2886015910 hasOpenAccess W2886015910 @default.
- W2886015910 hasPrimaryLocation W28860159101 @default.
- W2886015910 hasRelatedWork W2044850629 @default.
- W2886015910 hasRelatedWork W2585474788 @default.
- W2886015910 hasRelatedWork W2741137777 @default.
- W2886015910 hasRelatedWork W2752704023 @default.
- W2886015910 hasRelatedWork W2886015910 @default.
- W2886015910 hasRelatedWork W2953948952 @default.
- W2886015910 hasRelatedWork W2986971615 @default.
- W2886015910 hasRelatedWork W3030491230 @default.
- W2886015910 hasRelatedWork W4207077013 @default.
- W2886015910 hasRelatedWork W4210899872 @default.
- W2886015910 isParatext "false" @default.
- W2886015910 isRetracted "false" @default.
- W2886015910 magId "2886015910" @default.
- W2886015910 workType "article" @default.