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• W2886059343 abstract "BackgroundSevere and medication-resistant psychiatric diseases, such as major depressive disorder, bipolar disorder or schizophrenia, can be effectively and rapidly treated by electroconvulsive therapy (ECT). Despite extensive long-standing clinical use, the neurobiological mechanisms underlying the curative action of ECT remain incompletely understood.ObjectiveUnravel biological basis of electroconvulsive stimulation (ECS) efficacy, the animal equivalent of ECT.MethodsUsing MAP6 KO mouse, a genetic model that constitutively exhibits features relevant to some aspects of depression; we analyzed the behavioral and biological consequences of ECS treatment alone (10 stimulations over a 2-week period) and associated with a continuation protocol (2 stimulations per week for 5 weeks).ResultsECS treatment had a beneficial effect on constitutive behavioral defects. We showed that behavioral improvement is associated with a strong increase in the survival and integration of neurons born before ECS treatment. Retroviral infection revealed the larger number of integrated neurons to exhibit increased dendritic complexity and spine density, as well as remodeled synapses. Furthermore, our results show that ECS triggers a cortical increase in synaptogenesis. A sustained newborn neuron survival rate, induced by ECS treatment, is associated with the behavioral improvement, but relapse occurred 40 days after completing the ECS treatment. However, a 5-week continuation protocol following the initial ECS treatment led to persistent improvement of behavior correlated with sustained rate survival of newborn neurons.ConclusionAltogether, these results reveal that increased synaptic connectivity and extended neuronal survival are key to the short and long-term efficacy of ECS." @default.
• W2886059343 created "2018-08-22" @default.
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• W2886059343 date "2018-11-01" @default.
• W2886059343 modified "2023-10-11" @default.
• W2886059343 title "Short- and long-term efficacy of electroconvulsive stimulation in animal models of depression: The essential role of neuronal survival" @default.
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• W2886059343 doi "https://doi.org/10.1016/j.brs.2018.08.001" @default.
• W2886059343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30146428" @default.
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