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- W2886070493 abstract "OBJECTIVE: Serum Paraoxonase1 (PON1) is involved in the metabolism of Organophosphorous (OP) compounds. PON1 is polymorphic and at least three phenotypes have been described so far. The phenotypic polymorphism of PON1 may affect the susceptibility of patients to OPC toxicity. This study is focused on the evaluation of phenotypic enzyme activities of serum Paraoxonase1 (PON1) and its relationship with serum Cholinesterase activity in 54 patients with Acute Organophosphorus compound (OPC) poisoning.MATERIALS AND METHODS: Serum paraoxonase and arylesterase activities of PON1 were estimated in dual beam spectrophotometer. Serum Cholinesterase activity was measured in Semiautoanalyser. The results were analyzed using SPSS version 16, where ‘one way ANOVA’ was used to compare mean values of variables among PON1 phenotypes and correlation analysis was done with ‘Pearson coefficient of correlation’.RESULTS: Mean values of activity of Cholinesterase, Paraoxonase, Arylesterase were 2325 (SD ± 2027.19) U/L; 218.39 (SD ± 124.30) U/L; and 85.13 (SD ± 30.19) kU/L respectively. Activity of all three enzymes viz., Cholinesterase, Paraoxonase, Arylesterase varied with respect to PON1 phenotypes. PON1 BB phenotype has high Paraoxonase and Cholinesterase activity whereas AA phenotype has low Paraoxonase and Cholinesterase activity and the AB phenotype was reported with in between activity. Serum Cholinesterase was correlated positively and significantly with serum Paraoxonase (Coefficient of Correlation, r = +0.767, with p value < 0.0001) as well as with serum Paraoxonase/Arylesterase activity (P/A) (Coefficient of Correlation, r = +0.955, with p value < 0.0001) which was used to determine PON1 phenotypes.CONCLUSION: To conclude, in case of Acute OPC poisoning, identification of PON1 phenotype can be useful to identify the susceptibility of patients to OPC toxicity." @default.
- W2886070493 created "2018-08-22" @default.
- W2886070493 creator A5074622094 @default.
- W2886070493 date "2015-04-01" @default.
- W2886070493 modified "2023-09-27" @default.
- W2886070493 title "A Study on Phenotypic Polymorphism of Serum Paraoxonase1 and Activity of Serum Cholinesterase in Acute OrganophosphorousCompound Poisoning" @default.
- W2886070493 hasPublicationYear "2015" @default.
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