FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886103417> ?p ?o ?g. }

• W2886103417 endingPage "5346" @default.
• W2886103417 startingPage "5335" @default.
• W2886103417 abstract "Purpose: To develop a synergistic combination therapy for advanced pancreatic cancer, using local phototherapy and immunotherapy, and to determine the efficacy and mechanism of the novel combination therapy using a highly metastatic pancreatic tumor model in mice.Experimental Design: Mice bearing Panc02-H7 pancreatic tumors (both subcutaneous and orthotopic) were treated with noninvasive or interventional photothermal therapy, followed by local application of an immunoadjuvant. Tumor growth and animal survival were assessed. Immune cell populations within spleen and tumors were evaluated by FACS and IHC, and cytokine levels were determined by ELISA.Results: Up to 75% of mice bearing subcutaneous tumors treated with combination therapy had complete tumor regression. Local photothermal therapy exposed/released damage-associated molecular patterns, which initiated an immunogenic tumor cell death, resulting in infiltration of antigen-presenting cells and Th1 immunity. Concomitant application of immunoadjuvant amplified Th1 immunity, especially the tumor-specific cytotoxic T lymphocyte response, with increased quantity and quality of T cells. Combination therapy also induced tumor-specific immune memory, as demonstrated by resistance to tumor rechallenge and production of memory T cells. For the treatment of orthotopic tumor, the combination therapy significantly reduced the primary tumors and metastases, and prolonged the animal survival time.Conclusions: This study indicated that combination of local phototherapy and immunotherapy induced a systemic immunity against established tumors and metastases in an aggressive, preclinical pancreatic tumor model, leading to a potential clinical method for patients with advanced pancreatic cancer. Clin Cancer Res; 24(21); 5335-46. ©2018 AACR." @default.
• W2886103417 created "2018-08-22" @default.
• W2886103417 creator A5001447073 @default.
• W2886103417 creator A5009905683 @default.
• W2886103417 creator A5011227285 @default.
• W2886103417 creator A5021081534 @default.
• W2886103417 creator A5050344464 @default.
• W2886103417 creator A5052663273 @default.
• W2886103417 creator A5077972623 @default.
• W2886103417 date "2018-11-01" @default.
• W2886103417 modified "2023-10-17" @default.
• W2886103417 title "Local Phototherapy Synergizes with Immunoadjuvant for Treatment of Pancreatic Cancer through Induced Immunogenic Tumor Vaccine" @default.
• W2886103417 cites W1497894656 @default.
• W2886103417 cites W1538210790 @default.
• W2886103417 cites W1939125543 @default.
• W2886103417 cites W1975873516 @default.
• W2886103417 cites W1995763089 @default.
• W2886103417 cites W1999998145 @default.
• W2886103417 cites W2015095309 @default.
• W2886103417 cites W2028366196 @default.
• W2886103417 cites W2030908446 @default.
• W2886103417 cites W2034269797 @default.
• W2886103417 cites W2044835625 @default.
• W2886103417 cites W2046041427 @default.
• W2886103417 cites W2055132644 @default.
• W2886103417 cites W2075879891 @default.
• W2886103417 cites W2083550744 @default.
• W2886103417 cites W2093887577 @default.
• W2886103417 cites W2096825083 @default.
• W2886103417 cites W2104987742 @default.
• W2886103417 cites W2120426523 @default.
• W2886103417 cites W2122924344 @default.
• W2886103417 cites W2124189941 @default.
• W2886103417 cites W2128488009 @default.
• W2886103417 cites W2130368065 @default.
• W2886103417 cites W2131104906 @default.
• W2886103417 cites W2137273795 @default.
• W2886103417 cites W2140649712 @default.
• W2886103417 cites W2144887013 @default.
• W2886103417 cites W2154203858 @default.
• W2886103417 cites W2155718471 @default.
• W2886103417 cites W2160860777 @default.
• W2886103417 cites W2162891536 @default.
• W2886103417 cites W2164801443 @default.
• W2886103417 cites W2165871546 @default.
• W2886103417 cites W2209812019 @default.
• W2886103417 cites W2279139042 @default.
• W2886103417 cites W2292286849 @default.
• W2886103417 cites W2292411590 @default.
• W2886103417 cites W2320698552 @default.
• W2886103417 cites W2482610426 @default.
• W2886103417 cites W2563099056 @default.
• W2886103417 cites W2576658154 @default.
• W2886103417 cites W2605366445 @default.
• W2886103417 cites W2729840551 @default.
• W2886103417 cites W2781525129 @default.
• W2886103417 cites W2905545823 @default.
• W2886103417 cites W4365787721 @default.
• W2886103417 doi "https://doi.org/10.1158/1078-0432.ccr-18-1126" @default.
• W2886103417 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6214772" @default.
• W2886103417 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30068705" @default.
• W2886103417 hasPublicationYear "2018" @default.
• W2886103417 type Work @default.
• W2886103417 sameAs 2886103417 @default.
• W2886103417 citedByCount "75" @default.
• W2886103417 countsByYear W28861034172019 @default.
• W2886103417 countsByYear W28861034172020 @default.
• W2886103417 countsByYear W28861034172021 @default.
• W2886103417 countsByYear W28861034172022 @default.
• W2886103417 countsByYear W28861034172023 @default.
• W2886103417 crossrefType "journal-article" @default.
• W2886103417 hasAuthorship W2886103417A5001447073 @default.
• W2886103417 hasAuthorship W2886103417A5009905683 @default.
• W2886103417 hasAuthorship W2886103417A5011227285 @default.
• W2886103417 hasAuthorship W2886103417A5021081534 @default.
• W2886103417 hasAuthorship W2886103417A5050344464 @default.
• W2886103417 hasAuthorship W2886103417A5052663273 @default.
• W2886103417 hasAuthorship W2886103417A5077972623 @default.
• W2886103417 hasBestOaLocation W28861034171 @default.
• W2886103417 hasConcept C121608353 @default.
• W2886103417 hasConcept C126322002 @default.
• W2886103417 hasConcept C203014093 @default.
• W2886103417 hasConcept C2776999253 @default.
• W2886103417 hasConcept C2777701055 @default.
• W2886103417 hasConcept C2777877232 @default.
• W2886103417 hasConcept C2777996000 @default.
• W2886103417 hasConcept C2779341262 @default.
• W2886103417 hasConcept C2780210213 @default.
• W2886103417 hasConcept C2909935589 @default.
• W2886103417 hasConcept C502942594 @default.
• W2886103417 hasConcept C71924100 @default.
• W2886103417 hasConcept C8891405 @default.
• W2886103417 hasConceptScore W2886103417C121608353 @default.
• W2886103417 hasConceptScore W2886103417C126322002 @default.
• W2886103417 hasConceptScore W2886103417C203014093 @default.
• W2886103417 hasConceptScore W2886103417C2776999253 @default.
• W2886103417 hasConceptScore W2886103417C2777701055 @default.
• W2886103417 hasConceptScore W2886103417C2777877232 @default.

• next