FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886113381> ?p ?o ?g. }

• W2886113381 endingPage "4709" @default.
• W2886113381 startingPage "4701" @default.
• W2886113381 abstract "Metastasis is the major cause of cancer-related deaths in patients with colon cancer, however, the exact molecular mechanism is unclear. MicroRNAs (miRNAs) play an important role in the pathogenesis and progression of cancer. Therefore, in this study, we aimed to identify differentially expressed miRNAs in two colon carcinoma cell lines: SW480, derived from primary colon carcinoma and SW620, derived from lymph node metastasis, which were obtained from the same patient.Three independent samples of cancer cells were collected from SW480 and SW620 cells, respectively. An miRNA microarray platform, miRCURY LNA™ microRNA array with 1,223 probes containing 3,000 capture probes, was used to determine the miRNA expression profiles of these two cell lines. Differentially expressed miRNAs were validated by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).The raw data were submitted to the Gene Expression Omnibus database (GSE72412). Thirteen miRNAs were differentially expressed between SW480 and SW620 cells, of which, seven miRNAs (hsa-miR-920, hsa-miR-636, hsa-miR-766-3p, hsa-miR-545-5p, hsa-miR-195-3p, hsa-miR-125a-3p, and hsa-miR-196b-3p) were found to be upregulated and six miRNAs (hsa-miR-3613-3p, hsa-miR-29b-3p, hsa-miR-1297, hsa-miR-141-5p, hsa-miR-200c-3p, and hsa-miR-141-3p) were found to be downregulated. Target analysis of the predicted miRNAs showed that these genes were primarily involved in protein binding, cell adhesion, and cancer metastasis. Furthermore, qRT-PCR validated the results of miRNA microarray.This is the first systematic analysis of the differences of miRNAs between SW480 and SW620 cells. The results provide useful information to explore potential biomarkers of miRNAs for predicting colon cancer metastasis." @default.
• W2886113381 created "2018-08-22" @default.
• W2886113381 creator A5024409317 @default.
• W2886113381 creator A5029176240 @default.
• W2886113381 creator A5076067265 @default.
• W2886113381 creator A5084150986 @default.
• W2886113381 date "2018-08-01" @default.
• W2886113381 modified "2023-10-18" @default.
• W2886113381 title "Characterization of microRNA expression in primary human colon adenocarcinoma cells (SW480) and their lymph node metastatic derivatives (SW620)" @default.
• W2886113381 cites W1492901739 @default.
• W2886113381 cites W1946170591 @default.
• W2886113381 cites W1964263352 @default.
• W2886113381 cites W1982666068 @default.
• W2886113381 cites W1990868443 @default.
• W2886113381 cites W1993083676 @default.
• W2886113381 cites W2000322921 @default.
• W2886113381 cites W2001563808 @default.
• W2886113381 cites W2042865509 @default.
• W2886113381 cites W2048008562 @default.
• W2886113381 cites W2097681338 @default.
• W2886113381 cites W2339549122 @default.
• W2886113381 cites W2520061116 @default.
• W2886113381 cites W2525702246 @default.
• W2886113381 cites W2583315249 @default.
• W2886113381 cites W2588025094 @default.
• W2886113381 cites W2595251399 @default.
• W2886113381 cites W2600458647 @default.
• W2886113381 cites W2611217613 @default.
• W2886113381 cites W2742175163 @default.
• W2886113381 cites W2742677820 @default.
• W2886113381 cites W2743299969 @default.
• W2886113381 cites W2746514272 @default.
• W2886113381 cites W2755419034 @default.
• W2886113381 cites W2760109676 @default.
• W2886113381 cites W2760323384 @default.
• W2886113381 cites W2770552571 @default.
• W2886113381 cites W2989377966 @default.
• W2886113381 doi "https://doi.org/10.2147/ott.s169233" @default.
• W2886113381 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6091476" @default.
• W2886113381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30127618" @default.
• W2886113381 hasPublicationYear "2018" @default.
• W2886113381 type Work @default.
• W2886113381 sameAs 2886113381 @default.
• W2886113381 citedByCount "21" @default.
• W2886113381 countsByYear W28861133812018 @default.
• W2886113381 countsByYear W28861133812019 @default.
• W2886113381 countsByYear W28861133812020 @default.
• W2886113381 countsByYear W28861133812021 @default.
• W2886113381 countsByYear W28861133812022 @default.
• W2886113381 countsByYear W28861133812023 @default.
• W2886113381 crossrefType "journal-article" @default.
• W2886113381 hasAuthorship W2886113381A5024409317 @default.
• W2886113381 hasAuthorship W2886113381A5029176240 @default.
• W2886113381 hasAuthorship W2886113381A5076067265 @default.
• W2886113381 hasAuthorship W2886113381A5084150986 @default.
• W2886113381 hasBestOaLocation W28861133811 @default.
• W2886113381 hasConcept C104317684 @default.
• W2886113381 hasConcept C121608353 @default.
• W2886113381 hasConcept C145059251 @default.
• W2886113381 hasConcept C150194340 @default.
• W2886113381 hasConcept C153911025 @default.
• W2886113381 hasConcept C186836561 @default.
• W2886113381 hasConcept C2779013556 @default.
• W2886113381 hasConcept C4692481 @default.
• W2886113381 hasConcept C502942594 @default.
• W2886113381 hasConcept C526805850 @default.
• W2886113381 hasConcept C54355233 @default.
• W2886113381 hasConcept C8415881 @default.
• W2886113381 hasConcept C86803240 @default.
• W2886113381 hasConceptScore W2886113381C104317684 @default.
• W2886113381 hasConceptScore W2886113381C121608353 @default.
• W2886113381 hasConceptScore W2886113381C145059251 @default.
• W2886113381 hasConceptScore W2886113381C150194340 @default.
• W2886113381 hasConceptScore W2886113381C153911025 @default.
• W2886113381 hasConceptScore W2886113381C186836561 @default.
• W2886113381 hasConceptScore W2886113381C2779013556 @default.
• W2886113381 hasConceptScore W2886113381C4692481 @default.
• W2886113381 hasConceptScore W2886113381C502942594 @default.
• W2886113381 hasConceptScore W2886113381C526805850 @default.
• W2886113381 hasConceptScore W2886113381C54355233 @default.
• W2886113381 hasConceptScore W2886113381C8415881 @default.
• W2886113381 hasConceptScore W2886113381C86803240 @default.
• W2886113381 hasLocation W28861133811 @default.
• W2886113381 hasLocation W28861133812 @default.
• W2886113381 hasLocation W28861133813 @default.
• W2886113381 hasLocation W28861133814 @default.
• W2886113381 hasLocation W28861133815 @default.
• W2886113381 hasOpenAccess W2886113381 @default.
• W2886113381 hasPrimaryLocation W28861133811 @default.
• W2886113381 hasRelatedWork W1879733234 @default.
• W2886113381 hasRelatedWork W1983994322 @default.
• W2886113381 hasRelatedWork W2006024165 @default.
• W2886113381 hasRelatedWork W2053053668 @default.
• W2886113381 hasRelatedWork W2362238002 @default.
• W2886113381 hasRelatedWork W2373357709 @default.
• W2886113381 hasRelatedWork W2383598698 @default.
• W2886113381 hasRelatedWork W2415025170 @default.
• W2886113381 hasRelatedWork W2900947575 @default.

• next