FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886134329> ?p ?o ?g. }

• W2886134329 endingPage "192" @default.
• W2886134329 startingPage "184" @default.
• W2886134329 abstract "Aβ1-42 is well accepted to be a primary early pathogenic agent in Alzheimer's disease (AD). However, other amyloid peptides are now gaining considerable attention as potential key participants in AD due to their proposed higher neuronal toxicity. Impairment of the glutamatergic system is also widely accepted to be associated with pathomechanisms underlying AD. There is ample evidence that Aβ1-42 affects GLUN2B subunit containing N-methyl-D-aspartate receptor function and abolishes the induction of long term potentiation (LTP). In this study we show that different β-amyloid species, 1–42 Aβ1-42 and 1–40 (Aβ1-40) as well as post-translationally modified forms such as pyroglutamate-modified amyloid-(AβpE3) and nitrated Aβ (3NTyr10-Aβ), when applied for 90 min to murine hippocampal slices, concentration-dependently prevented the development of CA1-LTP after tetanic stimulation of the Schaffer collaterals with IC50s of 2, 9, 2 and 35 nM, respectively whilst having no effect on baseline AMPA receptor mediated fEPSPs. Aβ1-43 had no effect. Interestingly, the combination of all Aβ species did not result in any synergistic or additive inhibitory effect on LTP - the calculated pooled Aβ species IC50 was 20 nM. A low concentration (10 nM) of the GLUN2B receptor antagonist Radiprodil restored LTP in the presence of Aβ1-42, 3NTyr10-Aβ, Aβ1-40, but not AβpE3. In contrast to AMPA receptor mediated fEPSPs, all different β-amyloid species tested at 50 nM supressed baseline NMDA-EPSC amplitudes. Similarly, all different Aβ species tested decreased spine density. As with LTP, Radiprodil (10 nM) reversed the synaptic toxicity of Aβ species but not that of AβpE3. These data do not support the enhanced toxic actions reported for some Aβ species such as AβpE3, nor synergistic toxicity of the combination of different Aβ species. However, whilst in our hands AβpE3-42 was actually less toxic than Aβ1-42, its effects were not reversed by Radiprodil indicating that the target receptors/subunits mediating such synaptotoxicity may differ between the different Aβ species tested." @default.
• W2886134329 created "2018-08-22" @default.
• W2886134329 creator A5033026625 @default.
• W2886134329 creator A5034961772 @default.
• W2886134329 creator A5035241866 @default.
• W2886134329 creator A5056816961 @default.
• W2886134329 creator A5057517491 @default.
• W2886134329 creator A5058923599 @default.
• W2886134329 creator A5069184646 @default.
• W2886134329 creator A5071702581 @default.
• W2886134329 creator A5078440867 @default.
• W2886134329 date "2018-09-01" @default.
• W2886134329 modified "2023-10-16" @default.
• W2886134329 title "The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aβ) species on long-term potentiation (LTP)" @default.
• W2886134329 cites W1561114541 @default.
• W2886134329 cites W1587774683 @default.
• W2886134329 cites W1595726542 @default.
• W2886134329 cites W1637989849 @default.
• W2886134329 cites W1861171670 @default.
• W2886134329 cites W1876061808 @default.
• W2886134329 cites W1964587084 @default.
• W2886134329 cites W1967464880 @default.
• W2886134329 cites W1968024448 @default.
• W2886134329 cites W1977823998 @default.
• W2886134329 cites W1980340730 @default.
• W2886134329 cites W1980937139 @default.
• W2886134329 cites W1988718039 @default.
• W2886134329 cites W1990350348 @default.
• W2886134329 cites W1990632702 @default.
• W2886134329 cites W1993465897 @default.
• W2886134329 cites W1995718400 @default.
• W2886134329 cites W1999017783 @default.
• W2886134329 cites W2003655335 @default.
• W2886134329 cites W2007495000 @default.
• W2886134329 cites W2009828191 @default.
• W2886134329 cites W2019110724 @default.
• W2886134329 cites W2025561374 @default.
• W2886134329 cites W2033354781 @default.
• W2886134329 cites W2033554275 @default.
• W2886134329 cites W2039826986 @default.
• W2886134329 cites W2046484785 @default.
• W2886134329 cites W2051268743 @default.
• W2886134329 cites W2051314670 @default.
• W2886134329 cites W2052712042 @default.
• W2886134329 cites W2054628503 @default.
• W2886134329 cites W2058611995 @default.
• W2886134329 cites W2061387301 @default.
• W2886134329 cites W2069750066 @default.
• W2886134329 cites W2070071706 @default.
• W2886134329 cites W2072720067 @default.
• W2886134329 cites W2074493381 @default.
• W2886134329 cites W2075481535 @default.
• W2886134329 cites W2075967168 @default.
• W2886134329 cites W2078917784 @default.
• W2886134329 cites W2079912519 @default.
• W2886134329 cites W2081070804 @default.
• W2886134329 cites W2082151254 @default.
• W2886134329 cites W2083663079 @default.
• W2886134329 cites W2084973310 @default.
• W2886134329 cites W2088897156 @default.
• W2886134329 cites W2094541430 @default.
• W2886134329 cites W2095422335 @default.
• W2886134329 cites W2096557110 @default.
• W2886134329 cites W2103440561 @default.
• W2886134329 cites W2109171315 @default.
• W2886134329 cites W2113476104 @default.
• W2886134329 cites W2114163624 @default.
• W2886134329 cites W2116489922 @default.
• W2886134329 cites W2117396078 @default.
• W2886134329 cites W2124134368 @default.
• W2886134329 cites W2125614519 @default.
• W2886134329 cites W2126607520 @default.
• W2886134329 cites W2126958454 @default.
• W2886134329 cites W2138008971 @default.
• W2886134329 cites W2147490536 @default.
• W2886134329 cites W2147654688 @default.
• W2886134329 cites W2150088372 @default.
• W2886134329 cites W2150999725 @default.
• W2886134329 cites W2155580811 @default.
• W2886134329 cites W2158273573 @default.
• W2886134329 cites W2162124438 @default.
• W2886134329 cites W2162807572 @default.
• W2886134329 cites W2168901397 @default.
• W2886134329 cites W2170085655 @default.
• W2886134329 cites W2258879186 @default.
• W2886134329 cites W2269394021 @default.
• W2886134329 cites W2301943443 @default.
• W2886134329 cites W2549981621 @default.
• W2886134329 cites W2585261722 @default.
• W2886134329 cites W2591812992 @default.
• W2886134329 cites W2745468811 @default.
• W2886134329 cites W2783030886 @default.
• W2886134329 cites W54300931 @default.
• W2886134329 doi "https://doi.org/10.1016/j.neuropharm.2018.07.021" @default.
• W2886134329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30016667" @default.
• W2886134329 hasPublicationYear "2018" @default.
• W2886134329 type Work @default.
• W2886134329 sameAs 2886134329 @default.

• next