FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886148643> ?p ?o ?g. }

• W2886148643 endingPage "374" @default.
• W2886148643 startingPage "364" @default.
• W2886148643 abstract "The objective was to determine if there is a difference in procedural amnesia and adverse respiratory events (AREs) between the target sedation levels of moderate (MS) and deep (DS) procedural sedation.This was a prospective, randomized clinical trial of consenting adult patients planning to undergo DS with propofol between March 5, 2015, and May 24, 2017. Patients were randomized to a target sedation level of MS or DS using the American Society of Anesthesiologist's definitions. Drug doses, vital signs, observer's assessment of alertness/sedation (OAAS) score, end-tidal CO2 (ETCO2 ), and the need for supportive airway maneuvers (SAMs; bag-valve mask use, repositioning, and stimulation to induce respirations) were monitored continuously. A standardized image was shown every 30 seconds starting 3 minutes before the procedure continuing until the patient had returned to baseline after the procedure. Recall and recognition of images were assessed 10 minutes after the sedation. Subclinical respiratory depression (RD) was defined as SaO2 ≤ 91%, change in ETCO2 ≥ 10 mm Hg, or absent ETCO2 at any time. The occurrence of RD with a SAM was defined as an ARE. Patient satisfaction, pain, and perceived recollection and physician assessment of procedure difficulty were collected using visual analog scales (VASs). Data were analyzed with descriptive statistics and Wilcoxon rank-sum test.A total of 107 patients were enrolled: 54 randomized to target MS and 53 to DS. Of the patients randomized to target MS, 50% achieved MS and 50% achieved DS. In the target DS group, 77% achieved DS and 23% achieved MS. The median total propofol dose (mg/kg) was lower in the MS group: MS 1.4 (95% confidence interval [CI] = 1.3-1.6, IQR = 1) versus DS 1.8 (95% CI = 1.6-2.0, IQR = 0.9). There were no differences in median OAAS during the procedure (MS 2.4 and DS 2.8), lowest OAAS (MS 2 and DS 2), percentage of images recalled (MS 4.7% vs. DS 3.8%, p = 0.73), or percentage of images recognized (MS 61.1% vs. DS 55%, p = 0.52). In the MS group, 41% patients had any AREs compared to 42% in the DS group (p = 0.77, 95% CI difference = -0.12 to 0.24). The total number of AREs was 23% lower in the MS group (p = 0.01, 95% CI = -0.41 to -0.04). There was no difference in patient-reported pain, satisfaction, or recollection VAS scores. Provider's rating of procedural difficulty and procedural success were similar in both groups.Targeting MS or DS did not reliably result in the intended sedation level. Targeting MS, however, resulted in a lower rate of total AREs and fewer patients had multiple AREs with no difference in procedural recall. As seen in previous reports, patients who achieved MS had less AREs than those who achieved DS. Our study suggests that a target of MS provides adequate amnesia with less need for supportive airway interventions than a target level of DS, despite the fact that it often does not result in intended sedation level." @default.
• W2886148643 created "2018-08-22" @default.
• W2886148643 creator A5022767181 @default.
• W2886148643 creator A5023310280 @default.
• W2886148643 creator A5046578059 @default.
• W2886148643 creator A5066986460 @default.
• W2886148643 creator A5075900301 @default.
• W2886148643 date "2018-09-24" @default.
• W2886148643 modified "2023-09-27" @default.
• W2886148643 title "Randomized Clinical Trial Comparing Procedural Amnesia and Respiratory Depression Between Moderate and Deep Sedation With Propofol in the Emergency Department" @default.
• W2886148643 cites W190441754 @default.
• W2886148643 cites W1949708446 @default.
• W2886148643 cites W1968720830 @default.
• W2886148643 cites W2000924331 @default.
• W2886148643 cites W2037199501 @default.
• W2886148643 cites W2043929905 @default.
• W2886148643 cites W2046216703 @default.
• W2886148643 cites W2060046000 @default.
• W2886148643 cites W2065688518 @default.
• W2886148643 cites W2067026957 @default.
• W2886148643 cites W2074396726 @default.
• W2886148643 cites W2138487631 @default.
• W2886148643 cites W2139580351 @default.
• W2886148643 cites W2145851204 @default.
• W2886148643 cites W2170501185 @default.
• W2886148643 cites W2331498981 @default.
• W2886148643 cites W3023100843 @default.
• W2886148643 cites W4250507448 @default.
• W2886148643 doi "https://doi.org/10.1111/acem.13548" @default.
• W2886148643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30098230" @default.
• W2886148643 hasPublicationYear "2018" @default.
• W2886148643 type Work @default.
• W2886148643 sameAs 2886148643 @default.
• W2886148643 citedByCount "14" @default.
• W2886148643 countsByYear W28861486432020 @default.
• W2886148643 countsByYear W28861486432021 @default.
• W2886148643 countsByYear W28861486432022 @default.
• W2886148643 countsByYear W28861486432023 @default.
• W2886148643 crossrefType "journal-article" @default.
• W2886148643 hasAuthorship W2886148643A5022767181 @default.
• W2886148643 hasAuthorship W2886148643A5023310280 @default.
• W2886148643 hasAuthorship W2886148643A5046578059 @default.
• W2886148643 hasAuthorship W2886148643A5066986460 @default.
• W2886148643 hasAuthorship W2886148643A5075900301 @default.
• W2886148643 hasConcept C118552586 @default.
• W2886148643 hasConcept C126322002 @default.
• W2886148643 hasConcept C141071460 @default.
• W2886148643 hasConcept C168563851 @default.
• W2886148643 hasConcept C197934379 @default.
• W2886148643 hasConcept C2776277131 @default.
• W2886148643 hasConcept C2776814716 @default.
• W2886148643 hasConcept C2778615406 @default.
• W2886148643 hasConcept C2780724011 @default.
• W2886148643 hasConcept C42219234 @default.
• W2886148643 hasConcept C71924100 @default.
• W2886148643 hasConceptScore W2886148643C118552586 @default.
• W2886148643 hasConceptScore W2886148643C126322002 @default.
• W2886148643 hasConceptScore W2886148643C141071460 @default.
• W2886148643 hasConceptScore W2886148643C168563851 @default.
• W2886148643 hasConceptScore W2886148643C197934379 @default.
• W2886148643 hasConceptScore W2886148643C2776277131 @default.
• W2886148643 hasConceptScore W2886148643C2776814716 @default.
• W2886148643 hasConceptScore W2886148643C2778615406 @default.
• W2886148643 hasConceptScore W2886148643C2780724011 @default.
• W2886148643 hasConceptScore W2886148643C42219234 @default.
• W2886148643 hasConceptScore W2886148643C71924100 @default.
• W2886148643 hasIssue "4" @default.
• W2886148643 hasLocation W28861486431 @default.
• W2886148643 hasLocation W28861486432 @default.
• W2886148643 hasOpenAccess W2886148643 @default.
• W2886148643 hasPrimaryLocation W28861486431 @default.
• W2886148643 hasRelatedWork W1992744837 @default.
• W2886148643 hasRelatedWork W2018219218 @default.
• W2886148643 hasRelatedWork W2046685379 @default.
• W2886148643 hasRelatedWork W2123609241 @default.
• W2886148643 hasRelatedWork W2164829261 @default.
• W2886148643 hasRelatedWork W2369196009 @default.
• W2886148643 hasRelatedWork W2400477220 @default.
• W2886148643 hasRelatedWork W4248644417 @default.
• W2886148643 hasRelatedWork W77631183 @default.
• W2886148643 hasRelatedWork W413409146 @default.
• W2886148643 hasVolume "26" @default.
• W2886148643 isParatext "false" @default.
• W2886148643 isRetracted "false" @default.
• W2886148643 magId "2886148643" @default.
• W2886148643 workType "article" @default.