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- W2886154302 abstract "Significance The outer membrane of Gram-negative bacteria prevents the entry of many antibiotics and limits treatment options for Gram-negative infections. This unique membrane is effective due to its asymmetric lipid composition, with the glycolipid lipid A [LPS or lipooligosaccharide (LOS)] in the outer leaflet at the cell surface and glycerophospholipids in the inner leaflet. Furthering our understanding of how outer membrane asymmetry is maintained is critical for the development of novel therapeutics to target multidrug-resistant bacteria. Here, we used a Gram-negative bacterium without LOS to probe for factors that impact cell-envelope maintenance in the absence of LOS. Our approach enabled us to explore fundamental mechanisms of cell-envelope biology and expand our holistic view of the asymmetrical, Gram-negative outer membrane." @default.
- W2886154302 created "2018-08-22" @default.
- W2886154302 creator A5008763725 @default.
- W2886154302 creator A5073031989 @default.
- W2886154302 date "2018-08-07" @default.
- W2886154302 modified "2023-10-16" @default.
- W2886154302 title "Phospholipid retention in the absence of asymmetry strengthens the outer membrane permeability barrier to last-resort antibiotics" @default.
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- W2886154302 doi "https://doi.org/10.1073/pnas.1806714115" @default.
- W2886154302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6130378" @default.
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