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- W2886210164 abstract "For the first time, the structure of the receptor that is the predominant entry point for the AIDS virus to invade human cells has been determined. Knowing the form of the receptor, called CCR5, raises hopes for the discovery of drugs that can block human immunodeficiency virus more effectively than can the drug maraviroc. When HIV infects someone, it first interacts with CD4 receptors on immune-cell surfaces. This interaction opens the door for a secondary interaction with one of two coreceptors, CXCR4 or CCR5, which results in HIV’s cell entry. Of the two coreceptors, CCR5 is the more common entry point, and natural variations in CCR5 receptors can change a person’s risk of being infected by HIV. The crystal structure of CXCR4 bound to an antagonist (blocking agent) was obtained three years ago by Raymond C. Stevens of Scripps Research Institute California and coworkers, including postdoc Beili Wu. However, CCR5 ..." @default.
- W2886210164 created "2018-08-22" @default.
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- W2886210164 date "2013-09-16" @default.
- W2886210164 modified "2023-09-27" @default.
- W2886210164 title "Key HIV Entry Point Analyzed" @default.
- W2886210164 doi "https://doi.org/10.1021/cen-09137-notw10" @default.
- W2886210164 hasPublicationYear "2013" @default.
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