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- W2886218520 abstract "Pulmonary embolism (PE) contributes substantially to the global disease burden. A key determinant of early adverse outcomes is the presence (and severity) of right ventricular dysfunction. Consequently, risk-adapted management strategies continue to evolve, tailoring acute treatment to the patients’ clinical presentation, hemodynamic status, imaging and biochemical markers, and comorbidity. For subjects with hemodynamic instability or ‘high-risk’ PE, immediate systemic reperfusion treatment with intravenous thrombolysis is indicated; emerging approaches such as catheter-directed pharmacomechanical reperfusion might help to minimize the bleeding risk. Currently, direct, non-vitamin K-dependent oral anticoagulants are the mainstay of treatment for acute PE. They have been shown to simplify initial and extended anticoagulation regimens while reducing the bleeding risk compared to vitamin K antagonists. (This is a review article based on the invited lecture of the 37th Annual Meeting of Japanese Society of Phlebology.)" @default.
- W2886218520 created "2018-08-22" @default.
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- W2886218520 date "2018-09-25" @default.
- W2886218520 modified "2023-09-30" @default.
- W2886218520 title "Pulmonary Embolism: Contemporary Medical Management and Future Perspectives" @default.
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- W2886218520 doi "https://doi.org/10.3400/avd.ra.18-00054" @default.
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