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- W2886221108 abstract "There is a pressing need to develop novel therapies for myocardial infarction and heart failure, two conditions that affect over 20% of the world population. Despite important advances in achieving revascularization of the ischaemic myocardium and the usefulness of devices in assisting failing hearts, therapy for these conditions remains poor. The final extent of myocardial tissue loss after infarction is a major determinant of post-infarction mortality due to heart failure. In this chapter we review the current strategies aimed at counteracting injury due to acute myocardial ischaemia–reperfusion and the experimental approaches to achieve cardiac and vascular regeneration once damage has occurred. We critically discuss the possibility of inducing tissue restoration by gene transfer or exogenous cell implantation, and report on the exciting possibility of stimulating the endogenous capacity of cardiac regeneration using growth factors and small regulatory RNAs." @default.
- W2886221108 created "2018-08-22" @default.
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- W2886221108 date "2018-08-01" @default.
- W2886221108 modified "2023-09-22" @default.
- W2886221108 title "Advanced therapies to treat cardiovascular diseases: controversies and perspectives" @default.
- W2886221108 doi "https://doi.org/10.1093/med/9780198757269.003.0028" @default.
- W2886221108 hasPublicationYear "2018" @default.
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