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- W2886241489 abstract "Background—Congestive heart failure (CHF) is frequently associated with atrial fibrillation (AF), but little is known about the effects of CHF on atrial cellular electrophysiology. Methods and Results—We studied action potential (AP) properties and ionic currents in atrial myocytes from dogs with CHF induced by ventricular pacing at 220 to 240 bpm for 5 weeks. Atrial myocytes from CHF dogs were hypertrophied (mean±SEM capacitance, 89±2 pF versus 71±2 pF in control, n=160 cells per group, P<0.001). CHF significantly reduced the density of L-type Ca2+ current (ICa) by ≈30%, of transient outward K+ current (Ito) by ≈50%, and of slow delayed rectifier current (IKs) by ≈30% without altering their voltage dependencies or kinetics. The inward rectifier, ultrarapid and rapid delayed rectifier, and T-type Ca2+ currents were not altered by CHF. CHF increased transient inward Na+/Ca2+ exchanger (NCX) current by ≈45%. The AP duration of atrial myocytes was not altered by CHF at slow rates but was increased at faster ..." @default.
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- W2886241489 date "2000-06-06" @default.
- W2886241489 modified "2023-09-23" @default.
- W2886241489 title "Effects of Experimental Heart Failure on Atrial Cellular and Ionic Electrophysiology" @default.
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