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- W2886259987 abstract "Pseudophosphatases are atypical members of the protein tyrosine phosphatase superfamily. Mutations within their catalytic signature motif render them catalytically inactive. Despite this lack of catalytic function, pseudophosphatases have been implicated in various diseases such as Charcot Marie-Tooth disorder, cancer, metabolic disorder, and obesity. Moreover, they have roles in various signaling networks such as spermatogenesis, apoptosis, stress response, tumorigenesis, and neurite differentiation. This review highlights the roles of pseudophosphatases as essential regulators in signaling cascades, providing insight into the function of these catalytically inactive enzymes." @default.
- W2886259987 created "2018-08-22" @default.
- W2886259987 creator A5049728848 @default.
- W2886259987 date "2019-01-01" @default.
- W2886259987 modified "2023-10-13" @default.
- W2886259987 title "The role of pseudophosphatases as signaling regulators" @default.
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- W2886259987 doi "https://doi.org/10.1016/j.bbamcr.2018.07.021" @default.
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