Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886280007> ?p ?o ?g. }
- W2886280007 endingPage "35" @default.
- W2886280007 startingPage "1" @default.
- W2886280007 abstract "Protein tyrosine kinases (PTK), discovered in the 1970s, have been considered master regulators of biological processes with high clinical significance as targets for human diseases. Their actions are countered by protein tyrosine phosphatases (PTP), enzymes yet underrepresented as drug targets because of the high homology of their catalytic domains and high charge of their catalytic pocket. This scenario is still worse for some PTP subclasses, for example, for the atypical dual-specificity phosphatases (ADUSPs), whose biological functions are not even completely known. In this sense, the present work focuses on the dual-specificity phosphatase 3 (DUSP3), also known as VH1-related phosphatase (VHR), an uncommon regulator of mitogen-activated protein kinase (MAPK) phosphorylation. DUSP3 expression and activities are suggestive of a tumor suppressor or tumor-promoting enzyme in different types of human cancers. Furthermore, DUSP3 has other biological functions involving immune response mediation, thrombosis, hemostasis, angiogenesis, and genomic stability that occur through either MAPK-dependent or MAPK-independent mechanisms. This broad spectrum of actions is likely due to the large substrate diversity and molecular mechanisms that are still under scrutiny. The growing advances in characterizing new DUSP3 substrates will allow the development of pharmacological inhibitors relevant for possible future clinical trials. This review covers all aspects of DUSP3, since its gene cloning and crystallographic structure resolution, in addition to its classical and novel substrates and the biological processes involved, followed by an update of what is currently known about the DUSP3/VHR-inhibiting compounds that might be considered potential drugs to treat human diseases." @default.
- W2886280007 created "2018-08-22" @default.
- W2886280007 creator A5008281494 @default.
- W2886280007 creator A5017266289 @default.
- W2886280007 creator A5036373330 @default.
- W2886280007 creator A5053162710 @default.
- W2886280007 creator A5089651035 @default.
- W2886280007 date "2018-01-01" @default.
- W2886280007 modified "2023-09-25" @default.
- W2886280007 title "DUSP3/VHR: A Druggable Dual Phosphatase for Human Diseases" @default.
- W2886280007 cites W1239358504 @default.
- W2886280007 cites W1253834127 @default.
- W2886280007 cites W1491559816 @default.
- W2886280007 cites W1498892177 @default.
- W2886280007 cites W1511026292 @default.
- W2886280007 cites W1533516721 @default.
- W2886280007 cites W1554815317 @default.
- W2886280007 cites W1562951114 @default.
- W2886280007 cites W1621681231 @default.
- W2886280007 cites W1864025627 @default.
- W2886280007 cites W1966521400 @default.
- W2886280007 cites W1967441029 @default.
- W2886280007 cites W1967938513 @default.
- W2886280007 cites W1968220278 @default.
- W2886280007 cites W1968474526 @default.
- W2886280007 cites W1971436788 @default.
- W2886280007 cites W1971925780 @default.
- W2886280007 cites W1972152765 @default.
- W2886280007 cites W1973353041 @default.
- W2886280007 cites W1973916375 @default.
- W2886280007 cites W1978726103 @default.
- W2886280007 cites W1982565963 @default.
- W2886280007 cites W1986534651 @default.
- W2886280007 cites W1987653445 @default.
- W2886280007 cites W1989212867 @default.
- W2886280007 cites W1989899886 @default.
- W2886280007 cites W1990555927 @default.
- W2886280007 cites W1991477412 @default.
- W2886280007 cites W1992115778 @default.
- W2886280007 cites W1992361007 @default.
- W2886280007 cites W1992665238 @default.
- W2886280007 cites W1993338076 @default.
- W2886280007 cites W1994817846 @default.
- W2886280007 cites W1996124075 @default.
- W2886280007 cites W1997143297 @default.
- W2886280007 cites W2003940624 @default.
- W2886280007 cites W2005658600 @default.
- W2886280007 cites W2007877171 @default.
- W2886280007 cites W2011521748 @default.
- W2886280007 cites W2012915718 @default.
- W2886280007 cites W2013971359 @default.
- W2886280007 cites W2017182293 @default.
- W2886280007 cites W2021029128 @default.
- W2886280007 cites W2025247655 @default.
- W2886280007 cites W2027446232 @default.
- W2886280007 cites W2030205108 @default.
- W2886280007 cites W2030674478 @default.
- W2886280007 cites W2032054503 @default.
- W2886280007 cites W2038279824 @default.
- W2886280007 cites W2038433050 @default.
- W2886280007 cites W2039263429 @default.
- W2886280007 cites W2043216274 @default.
- W2886280007 cites W2043617798 @default.
- W2886280007 cites W2044947105 @default.
- W2886280007 cites W2045914521 @default.
- W2886280007 cites W2049215210 @default.
- W2886280007 cites W2051120695 @default.
- W2886280007 cites W2053494754 @default.
- W2886280007 cites W2056525663 @default.
- W2886280007 cites W2058705034 @default.
- W2886280007 cites W2063256489 @default.
- W2886280007 cites W2063333928 @default.
- W2886280007 cites W2068668324 @default.
- W2886280007 cites W2069985730 @default.
- W2886280007 cites W2070759617 @default.
- W2886280007 cites W2071900417 @default.
- W2886280007 cites W2074760218 @default.
- W2886280007 cites W2082843075 @default.
- W2886280007 cites W2082854050 @default.
- W2886280007 cites W2084734831 @default.
- W2886280007 cites W2085422820 @default.
- W2886280007 cites W2089381826 @default.
- W2886280007 cites W2089465915 @default.
- W2886280007 cites W2089739828 @default.
- W2886280007 cites W2091061305 @default.
- W2886280007 cites W2092058842 @default.
- W2886280007 cites W2098412103 @default.
- W2886280007 cites W2098962569 @default.
- W2886280007 cites W2099704580 @default.
- W2886280007 cites W2100050161 @default.
- W2886280007 cites W2100900404 @default.
- W2886280007 cites W2100920700 @default.
- W2886280007 cites W2100954321 @default.
- W2886280007 cites W2105332242 @default.
- W2886280007 cites W2105816640 @default.
- W2886280007 cites W2113352370 @default.
- W2886280007 cites W2117209575 @default.
- W2886280007 cites W2117258693 @default.