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- W2886284930 abstract "Abstract Traumatic brain injury (TBI) is a leading cause of death and disability in the United States. Primary brain injury occurs at the scene of the trauma when kinetic energy disrupts brain tissue. Secondary brain injury begins hours after the trauma and is caused by neurochemical, metabolic, and cellular changes. Blood–brain barrier permeability increases from the toxic environment created by secondary injury mechanisms. The ensuing cerebral edema amplifies the inflammatory signal by exacerbating the initial ischemic injury. Current TBI management strategies minimize secondary injury, because the primary injury is irreversible. Preclinical data demonstrate that stem cell therapies downregulate the intrinsic inflammatory response to TBI and upregulate the antiinflammatory response. Clinical trials show that stem cell therapies for TBI are a safe and logistically feasible way to preserve brain matter volume to potentially improve neurocognitive outcomes. Understanding cell therapy mechanisms of action will guide future clinical trial design." @default.
- W2886284930 created "2018-08-22" @default.
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- W2886284930 date "2019-01-01" @default.
- W2886284930 modified "2023-10-18" @default.
- W2886284930 title "Stem Cells for Traumatic Brain Injury" @default.
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- W2886284930 cites W1754067249 @default.
- W2886284930 cites W1836082148 @default.
- W2886284930 cites W1923917571 @default.
- W2886284930 cites W1964354605 @default.
- W2886284930 cites W1965953554 @default.
- W2886284930 cites W1966545752 @default.
- W2886284930 cites W1967239173 @default.
- W2886284930 cites W1969818897 @default.
- W2886284930 cites W1970107990 @default.
- W2886284930 cites W1970313665 @default.
- W2886284930 cites W1971218073 @default.
- W2886284930 cites W1982760076 @default.
- W2886284930 cites W1985269282 @default.
- W2886284930 cites W1987467195 @default.
- W2886284930 cites W1989614658 @default.
- W2886284930 cites W1989855011 @default.
- W2886284930 cites W1990574061 @default.
- W2886284930 cites W1991326785 @default.
- W2886284930 cites W1995316729 @default.
- W2886284930 cites W1997507612 @default.
- W2886284930 cites W2003785230 @default.
- W2886284930 cites W200476470 @default.
- W2886284930 cites W2005333810 @default.
- W2886284930 cites W2005848913 @default.
- W2886284930 cites W2018369199 @default.
- W2886284930 cites W2019476380 @default.
- W2886284930 cites W2022721144 @default.
- W2886284930 cites W2023542419 @default.
- W2886284930 cites W2023592432 @default.
- W2886284930 cites W2023755606 @default.
- W2886284930 cites W2032114206 @default.
- W2886284930 cites W2038650363 @default.
- W2886284930 cites W2038923714 @default.
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- W2886284930 cites W2044806819 @default.
- W2886284930 cites W2045663952 @default.
- W2886284930 cites W2047455245 @default.
- W2886284930 cites W2050800676 @default.
- W2886284930 cites W2056168675 @default.
- W2886284930 cites W2060319077 @default.
- W2886284930 cites W2062578821 @default.
- W2886284930 cites W2062949085 @default.
- W2886284930 cites W2064090932 @default.
- W2886284930 cites W2064787425 @default.
- W2886284930 cites W2068034427 @default.
- W2886284930 cites W2068118183 @default.
- W2886284930 cites W2069377303 @default.
- W2886284930 cites W2071115871 @default.
- W2886284930 cites W2074571304 @default.
- W2886284930 cites W2080881511 @default.
- W2886284930 cites W2089738396 @default.
- W2886284930 cites W2089940189 @default.
- W2886284930 cites W2091203314 @default.
- W2886284930 cites W2093825936 @default.
- W2886284930 cites W2094660330 @default.
- W2886284930 cites W2096019298 @default.
- W2886284930 cites W2098636250 @default.
- W2886284930 cites W2109518992 @default.
- W2886284930 cites W2110304980 @default.
- W2886284930 cites W2111727066 @default.
- W2886284930 cites W2116505148 @default.
- W2886284930 cites W2118501227 @default.
- W2886284930 cites W2118555325 @default.
- W2886284930 cites W2120377232 @default.
- W2886284930 cites W2122828560 @default.
- W2886284930 cites W2124248602 @default.
- W2886284930 cites W2124658196 @default.
- W2886284930 cites W2128916981 @default.
- W2886284930 cites W2134729461 @default.
- W2886284930 cites W2134785550 @default.
- W2886284930 cites W2135380777 @default.
- W2886284930 cites W2136677656 @default.
- W2886284930 cites W2146373526 @default.
- W2886284930 cites W2148450488 @default.
- W2886284930 cites W2158780936 @default.
- W2886284930 cites W2164068801 @default.
- W2886284930 cites W2268289085 @default.
- W2886284930 cites W2297402353 @default.
- W2886284930 cites W2319937456 @default.
- W2886284930 cites W2324995304 @default.
- W2886284930 cites W2592036189 @default.
- W2886284930 cites W2594748224 @default.
- W2886284930 cites W2595336446 @default.
- W2886284930 doi "https://doi.org/10.1016/b978-0-12-809880-6.00023-0" @default.
- W2886284930 hasPublicationYear "2019" @default.
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