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- W2886310275 abstract "IntroductionTendon cells originate from yet poorly described precursor cells and develop in a particular “niche” close to vascular walls. Several factors have been described to determine this niche such as mechanical stimuli, oxygen tension, composition and structure of the extracellular matrix (ECM). Also, the vasculature is considered to play a crucial role for tendon cell development, yet evidence of how this is accomplished is lacking. In this study we therefore focussed on the endothelium of tendon vessels postulating the existence of a paracellular barrier.Materials and MethodsBy electron microscopy, immunohistochemistry, and RT-PCR we investigated the presence of constituents making up such an endothelial barrier which we subsequently tested for its functionality by tracer injection. Moreover, we performed differentiation experiments into the adipogenic, chondrogenic and osteogenic lineage on tendon derived cells in the presence and absence of serum. Expression levels and activity of matrixmetallop..." @default.
- W2886310275 created "2018-08-22" @default.
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- W2886310275 date "2018-02-21" @default.
- W2886310275 modified "2023-09-23" @default.
- W2886310275 title "IDENTIFICATION AND CHARACTERISATION OF A NOVEL TISSUE BARRIER: THE BLOOD-TENDON BARRIER" @default.
- W2886310275 hasPublicationYear "2018" @default.
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