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- W2886322433 endingPage "1532" @default.
- W2886322433 startingPage "1522" @default.
- W2886322433 abstract "Iron(III) complexes of a vitamin B 6 Schiff base and NNN ‐donor ligands with pendant boron‐dipyrromethene (BODIPY) moieties; namely, [Fe(L 1–3 )(L 4,5 )](NO 3 ) ( 1 – 4 ), where L 1 is benzyl‐bis[(pyridin‐2‐yl)methyl]methanamine (bzdpa in 1 ), L 2 is a noniodinated BODIPY‐appended dipicolylamine ligand (in 2 , 3 ), L 3 is the diiodinated BODIPY analogue in 4 , L 4 is a vitamin B 6 Schiff base, namely 3‐hydroxy‐5(hydroxymethyl)‐4‐{[(2‐hydroxyphenyl)imino]methyl}‐2‐methylpyridine (in 1 , 3 , and 4 ), and L 5 is 2‐[(2‐hydroxyphenylimino)‐methyl]phenol (in 2 ) as a nonpyridoxal Schiff base, were prepared, characterized, and their cellular localization and cytotoxic activity in light and in the dark were studied. The diiodo–BODIPY complex 4 displays remarkable photoinduced cytotoxicity in visible light (400–700 nm), with IC 50 values within 0.11–0.25 µ m and about 200‐fold lower dark toxicity. Complex 3 , being fluorescent, was used for cellular imaging by confocal microscopy. Complex 4 shows supercoiled pUC19 DNA cleavage activity through the generation of singlet oxygen ( 1 O 2 ) as the reactive oxygen species (ROS). Selective uptake of the complexes is observed from competitive cellular incorporation assays in cancer and noncancer cells. The complexes also show no apparent toxicity up to 100 µ m in the immortal human lung epithelial cells HPL1D in both light and the dark. Complex 3 shows preferential accumulation in lysosomes, giving a Pearson's correlation coefficient value of about 0.7." @default.
- W2886322433 created "2018-08-22" @default.
- W2886322433 creator A5010638335 @default.
- W2886322433 creator A5038453259 @default.
- W2886322433 creator A5040082226 @default.
- W2886322433 creator A5045810532 @default.
- W2886322433 creator A5058711049 @default.
- W2886322433 creator A5072020392 @default.
- W2886322433 creator A5074837358 @default.
- W2886322433 creator A5074938996 @default.
- W2886322433 date "2018-04-06" @default.
- W2886322433 modified "2023-10-01" @default.
- W2886322433 title "Iron(III) Complexes of Vitamin B <sub>6</sub> Schiff Base with Boron‐Dipyrromethene Pendants for Lysosome‐Selective Photocytotoxicity" @default.
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