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- W2886330525 abstract "Global protein translation as well as translation at the codon level can be regulated by tRNA modifications. In eukaryotes, levels of tRNA queuosinylation reflect the bioavailability of the precursor queuine, which is salvaged from the diet and gut microbiota. We show here that nutritionally determined Q-tRNA levels promote Dnmt2-mediated methylation of tRNA Asp and control translational speed of Q-decoded codons as well as at near-cognate codons. Deregulation of translation upon queuine depletion results in unfolded proteins that trigger endoplasmic reticulum stress and activation of the unfolded protein response, both in cultured human cell lines and in germ-free mice fed with a queuosine-deficient diet. Taken together, our findings comprehensively resolve the role of this anticodon tRNA modification in the context of native protein translation and describe a novel mechanism that links nutritionally determined modification levels to effective polypeptide synthesis and cellular homeostasis." @default.
- W2886330525 created "2018-08-22" @default.
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- W2886330525 date "2018-08-09" @default.
- W2886330525 modified "2023-10-18" @default.
- W2886330525 title "Queuosine‐modified tRNAs confer nutritional control of protein translation" @default.
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- W2886330525 doi "https://doi.org/10.15252/embj.201899777" @default.
- W2886330525 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6138434" @default.
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