FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886334039> ?p ?o ?g. }

• W2886334039 abstract "Complex neurodevelopmental disorders need multi-disciplinary treatment approaches for optimal care. The clinical effectiveness of treatments is limited in patients with rare genetic syndromes with multisystem morbidity. Emotional and behavioural dysregulation is common across many neurodevelopmental disorders. It can manifest in children across multiple diagnostic groups, including those on the autism spectrum and in rare genetic syndromes such as Rett Syndrome (RTT). There is, however a remarkable scarcity in the literature on the impact of the autonomic component on emotional and behavioural regulation in these disorders, and on the longer-term outcomes on disorder burden.RTT is a debilitating and often life-threatening disorder involving multiple overlapping physiological systems. Autonomic dysregulation otherwise known as dysautonomia is a cardinal feature of RTT characterised by an imbalance between the sympathetic and parasympathetic arms of the autonomic nervous system. Unlocking the autonomic component of emotional and behavioural dysregulation would be central in reducing the impairment seen in patients with RTT. In this vein, Emotional, Behavioural and Autonomic Dysregulation (EBAD) would be a useful construct to target for treatment which could mitigate burden and improve the quality of life of patients.RTT can be considered as a congenital dysautonomia and because EBAD can give rise to impairments occurring in multiple overlapping physiological systems, understanding these physiological responses arising out of EBAD would be a critical part to consider when planning treatment strategies and improving clinical outcomes in these patients. Biometric guided pharmacological and bio-feedback therapy for the behavioural and emotional aspects of the disorder offers an attracting perspective to manage EBAD in these patients. This can also allow for the stratification of patients into clinical trials and could ultimately help streamline the patient care pathway for optimal outcomes.The objectives of this review are to emphasise the key issues relating to the management of EBAD in patients with RTT, appraise clinical trials done in RTT from the perspective of autonomic physiology and to discuss the potential of EBAD as a target for clinical trials." @default.
• W2886334039 created "2018-08-22" @default.
• W2886334039 creator A5035100919 @default.
• W2886334039 creator A5058598560 @default.
• W2886334039 date "2018-07-31" @default.
• W2886334039 modified "2023-09-23" @default.
• W2886334039 title "Key issues in Rett syndrome: emotional, behavioural and autonomic dysregulation (EBAD) - a target for clinical trials" @default.
• W2886334039 cites W145907347 @default.
• W2886334039 cites W1537651158 @default.
• W2886334039 cites W1565282672 @default.
• W2886334039 cites W1865706782 @default.
• W2886334039 cites W1914160091 @default.
• W2886334039 cites W196646972 @default.
• W2886334039 cites W1967698591 @default.
• W2886334039 cites W1969220135 @default.
• W2886334039 cites W1970165113 @default.
• W2886334039 cites W1971952955 @default.
• W2886334039 cites W1973284861 @default.
• W2886334039 cites W1980071917 @default.
• W2886334039 cites W1980683585 @default.
• W2886334039 cites W1982000098 @default.
• W2886334039 cites W1986992140 @default.
• W2886334039 cites W1990195559 @default.
• W2886334039 cites W1991674002 @default.
• W2886334039 cites W1996127418 @default.
• W2886334039 cites W1997201920 @default.
• W2886334039 cites W1999095568 @default.
• W2886334039 cites W1999441768 @default.
• W2886334039 cites W1999889452 @default.
• W2886334039 cites W2000308454 @default.
• W2886334039 cites W2002958204 @default.
• W2886334039 cites W2003739375 @default.
• W2886334039 cites W2006656814 @default.
• W2886334039 cites W2009703261 @default.
• W2886334039 cites W2013008152 @default.
• W2886334039 cites W2014597200 @default.
• W2886334039 cites W2017397382 @default.
• W2886334039 cites W2018175199 @default.
• W2886334039 cites W2021683084 @default.
• W2886334039 cites W2025732463 @default.
• W2886334039 cites W2026284384 @default.
• W2886334039 cites W2027347753 @default.
• W2886334039 cites W2032847934 @default.
• W2886334039 cites W2032901980 @default.
• W2886334039 cites W2034448311 @default.
• W2886334039 cites W2035016973 @default.
• W2886334039 cites W2038081845 @default.
• W2886334039 cites W2038290427 @default.
• W2886334039 cites W2041577838 @default.
• W2886334039 cites W2048282173 @default.
• W2886334039 cites W2051092571 @default.
• W2886334039 cites W2061123111 @default.
• W2886334039 cites W2066619092 @default.
• W2886334039 cites W2069088164 @default.
• W2886334039 cites W2071231392 @default.
• W2886334039 cites W2075213922 @default.
• W2886334039 cites W2075999647 @default.
• W2886334039 cites W2079937338 @default.
• W2886334039 cites W2080569433 @default.
• W2886334039 cites W2080674711 @default.
• W2886334039 cites W2082171245 @default.
• W2886334039 cites W2082684802 @default.
• W2886334039 cites W2085098641 @default.
• W2886334039 cites W2086670151 @default.
• W2886334039 cites W2086842197 @default.
• W2886334039 cites W2090453246 @default.
• W2886334039 cites W2092908962 @default.
• W2886334039 cites W2097431774 @default.
• W2886334039 cites W2097860753 @default.
• W2886334039 cites W2101105008 @default.
• W2886334039 cites W2101422709 @default.
• W2886334039 cites W2102533810 @default.
• W2886334039 cites W2104054545 @default.
• W2886334039 cites W2105938745 @default.
• W2886334039 cites W2109555365 @default.
• W2886334039 cites W2111772099 @default.
• W2886334039 cites W2112499943 @default.
• W2886334039 cites W2120502497 @default.
• W2886334039 cites W2121740489 @default.
• W2886334039 cites W2124955353 @default.
• W2886334039 cites W2125290408 @default.
• W2886334039 cites W2125348297 @default.
• W2886334039 cites W2130614276 @default.
• W2886334039 cites W2131837368 @default.
• W2886334039 cites W2133666546 @default.
• W2886334039 cites W2134540539 @default.
• W2886334039 cites W2134680293 @default.
• W2886334039 cites W2138024978 @default.
• W2886334039 cites W2138177351 @default.
• W2886334039 cites W2138507153 @default.
• W2886334039 cites W2139789471 @default.
• W2886334039 cites W2140170236 @default.
• W2886334039 cites W2142077480 @default.
• W2886334039 cites W2149612743 @default.
• W2886334039 cites W2151674741 @default.
• W2886334039 cites W2151975477 @default.
• W2886334039 cites W2154057943 @default.
• W2886334039 cites W2159140416 @default.
• W2886334039 cites W2159521444 @default.
• W2886334039 cites W2159814214 @default.

• next