Matches in SemOpenAlex for { <https://semopenalex.org/work/W2886345308> ?p ?o ?g. }
- W2886345308 endingPage "2698" @default.
- W2886345308 startingPage "2689" @default.
- W2886345308 abstract "The roles of surrounding membrane lipids in the functions of transmembrane and peripheral membrane proteins are largely unknown. Herein, we utilize the recently reported structures of the TRPV1 ion channel protein bound to its potent protein agonist, the double-knot toxin (DkTx), as a model system to investigate the roles of toxin–lipid interfaces in TRPV1 activation by characterizing a series of DkTx variants electrophysiologically. Together with membrane partitioning experiments, these studies reveal that toxin–lipid interfaces play an overwhelmingly dominant role in channel activation as compared to lipid-devoid toxin–channel interfaces. Additionally, we find that whereas the membrane interfaces formed by one of the knots of the toxin endow it with its low channel-dissociation rate, those formed by other knot contribute primarily to its potency. These studies establish that protein–lipid interfaces play nuanced yet profound roles in the function of protein–protein complexes within membranes." @default.
- W2886345308 created "2018-08-22" @default.
- W2886345308 creator A5041237847 @default.
- W2886345308 creator A5070779085 @default.
- W2886345308 creator A5083484457 @default.
- W2886345308 date "2018-08-06" @default.
- W2886345308 modified "2023-10-18" @default.
- W2886345308 title "Protein–Lipid Interfaces Can Drive the Functions of Membrane-Embedded Protein–Protein Complexes" @default.
- W2886345308 cites W1813097575 @default.
- W2886345308 cites W1966815375 @default.
- W2886345308 cites W1969129798 @default.
- W2886345308 cites W1973739970 @default.
- W2886345308 cites W1983904542 @default.
- W2886345308 cites W1996445293 @default.
- W2886345308 cites W2002449583 @default.
- W2886345308 cites W2002508442 @default.
- W2886345308 cites W2020444781 @default.
- W2886345308 cites W2020872723 @default.
- W2886345308 cites W2024609981 @default.
- W2886345308 cites W2026395206 @default.
- W2886345308 cites W2026582002 @default.
- W2886345308 cites W2039263844 @default.
- W2886345308 cites W2039493163 @default.
- W2886345308 cites W2040159113 @default.
- W2886345308 cites W2048754200 @default.
- W2886345308 cites W2049190436 @default.
- W2886345308 cites W2049748169 @default.
- W2886345308 cites W2051237359 @default.
- W2886345308 cites W2054342311 @default.
- W2886345308 cites W2056053405 @default.
- W2886345308 cites W2056961349 @default.
- W2886345308 cites W2070903093 @default.
- W2886345308 cites W2082531156 @default.
- W2886345308 cites W2084949662 @default.
- W2886345308 cites W2092318974 @default.
- W2886345308 cites W2096116156 @default.
- W2886345308 cites W2100595212 @default.
- W2886345308 cites W2104389482 @default.
- W2886345308 cites W2104415321 @default.
- W2886345308 cites W2130529910 @default.
- W2886345308 cites W2260335883 @default.
- W2886345308 cites W2404622021 @default.
- W2886345308 cites W2476984584 @default.
- W2886345308 cites W2588089291 @default.
- W2886345308 cites W2613712975 @default.
- W2886345308 cites W2771709052 @default.
- W2886345308 cites W2775458966 @default.
- W2886345308 cites W2782885942 @default.
- W2886345308 cites W4301859218 @default.
- W2886345308 cites W4376043503 @default.
- W2886345308 doi "https://doi.org/10.1021/acschembio.8b00644" @default.
- W2886345308 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6326545" @default.
- W2886345308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30080384" @default.
- W2886345308 hasPublicationYear "2018" @default.
- W2886345308 type Work @default.
- W2886345308 sameAs 2886345308 @default.
- W2886345308 citedByCount "7" @default.
- W2886345308 countsByYear W28863453082020 @default.
- W2886345308 countsByYear W28863453082022 @default.
- W2886345308 countsByYear W28863453082023 @default.
- W2886345308 crossrefType "journal-article" @default.
- W2886345308 hasAuthorship W2886345308A5041237847 @default.
- W2886345308 hasAuthorship W2886345308A5070779085 @default.
- W2886345308 hasAuthorship W2886345308A5083484457 @default.
- W2886345308 hasBestOaLocation W28863453081 @default.
- W2886345308 hasConcept C12554922 @default.
- W2886345308 hasConcept C144647389 @default.
- W2886345308 hasConcept C161200384 @default.
- W2886345308 hasConcept C170493617 @default.
- W2886345308 hasConcept C185592680 @default.
- W2886345308 hasConcept C24530287 @default.
- W2886345308 hasConcept C39944091 @default.
- W2886345308 hasConcept C41625074 @default.
- W2886345308 hasConcept C50254741 @default.
- W2886345308 hasConcept C55493867 @default.
- W2886345308 hasConcept C560191 @default.
- W2886345308 hasConcept C86803240 @default.
- W2886345308 hasConcept C95444343 @default.
- W2886345308 hasConceptScore W2886345308C12554922 @default.
- W2886345308 hasConceptScore W2886345308C144647389 @default.
- W2886345308 hasConceptScore W2886345308C161200384 @default.
- W2886345308 hasConceptScore W2886345308C170493617 @default.
- W2886345308 hasConceptScore W2886345308C185592680 @default.
- W2886345308 hasConceptScore W2886345308C24530287 @default.
- W2886345308 hasConceptScore W2886345308C39944091 @default.
- W2886345308 hasConceptScore W2886345308C41625074 @default.
- W2886345308 hasConceptScore W2886345308C50254741 @default.
- W2886345308 hasConceptScore W2886345308C55493867 @default.
- W2886345308 hasConceptScore W2886345308C560191 @default.
- W2886345308 hasConceptScore W2886345308C86803240 @default.
- W2886345308 hasConceptScore W2886345308C95444343 @default.
- W2886345308 hasFunder F4320307874 @default.
- W2886345308 hasFunder F4320320717 @default.
- W2886345308 hasFunder F4320320721 @default.
- W2886345308 hasFunder F4320324168 @default.
- W2886345308 hasIssue "9" @default.
- W2886345308 hasLocation W28863453081 @default.
- W2886345308 hasLocation W28863453082 @default.